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• W2005123107 abstract "The metabolic activation of promutagens by freshly isolated and cryopreserved rat hepatocytes was compared using the Chinese hamster ovary/hypoxanthine-guanine phosphoribosyltransferase assay (CHO/HGPRT). Cryopreserved rat hepatocytes were equivalent to freshly isolated hepatocytes in their ability to metabolize dimethylbenz(a)anthracene (DMBA) and dimethylnitrosamine (DMN) to active mutagens. Similar dose-response curves were observed using either freshly isolated or cryopreserved hepatocytes as activating systems after treatment with DMBA (0.1-1 μg/ml) and DMN (0.075-0.6 mg/ml). Our results suggest that cryopreserved hepatocytes are similar to freshly isolated hepatocytes as an experimental system for studies on promutagen activation." @default.
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• W2005123107 date "1988-01-01" @default.
• W2005123107 modified "2023-09-27" @default.
• W2005123107 title "Promutagen activation by freshly isolated and cryopreserved rat hepatocytes" @default.
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• W2005123107 doi "https://doi.org/10.1002/em.2860120308" @default.
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