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• W2005123729 abstract "The G-protein–coupled melanocortin receptors (MCRs) play an important role in a variety of essential functions such as the regulation of pigmentation, energy homeostasis, and steroid production. We performed a comprehensive characterization of the MC system in Fugu (Takifugu rubripes). We show that Fugu has an AGRP gene with high degree of conservation in the C-terminal region in addition to a POMC gene lacking γ-MSH. The Fugu genome contains single copies of four MCRs, whereas the MC3R is missing. The MC2R and MC5R are found in tandem and remarkably contain one and two introns, respectively. We suggest that these introns were inserted through a reverse splicing mechanism into the DRY motif that is widely conserved through GPCRs. We were able to assemble large blocks around the MCRs in Fugu, showing remarkable synteny with human chromosomes 16 and 18. Detailed pharmacological characterization showed that ACTH had surprisingly high affinity for the Fugu MC1R and MC4R, whereas α-MSH had lower affinity. We also showed that the MC2R gene in Fugu codes for an ACTH receptor, which did not respond to α-MSH. All the Fugu receptors were able to couple functionally to cAMP production in line with the mammalian orthologs. The anatomical characterization shows that the MC2R is expressed in the brain in addition to the head-kidney, whereas the MC4R and MC5R are found in both brain regions and peripheral tissues. This is the first comprehensive genomic and functional characterization of a GPCR family within the Fugu genome. The study shows that some parts of the MC system are highly conserved through vertebrate evolution, such as regions in POMC coding for ACTH, α-MSH, and β-MSH, the C-terminal region of AGRP, key binding units within the MC1R, MC2R, MC4R, and MC5R, synteny blocks around the MCRs, pharmacological properties of the MC2R, whereas other parts in the system are either missing, such as the MC3R and γ-MSH, or different as compared to mammals, such as the affinity of ACTH and MSH peptides to MC1R and MC4R and the anatomical expression pattern of the MCRs." @default.
• W2005123729 created "2016-06-24" @default.
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• W2005123729 date "2004-03-01" @default.
• W2005123729 modified "2023-10-01" @default.
• W2005123729 title "The Melanocortin System in Fugu: Determination of POMC/AGRP/MCR Gene Repertoire and Synteny, As Well As Pharmacology and Anatomical Distribution of the MCRs" @default.
• W2005123729 cites W1488596761 @default.
• W2005123729 cites W1503357410 @default.
• W2005123729 cites W1557479171 @default.
• W2005123729 cites W1779019576 @default.
• W2005123729 cites W1923477899 @default.
• W2005123729 cites W1964488668 @default.
• W2005123729 cites W1973772334 @default.
• W2005123729 cites W1983559681 @default.
• W2005123729 cites W1984622423 @default.
• W2005123729 cites W1985737359 @default.
• W2005123729 cites W1985948341 @default.
• W2005123729 cites W1993056869 @default.
• W2005123729 cites W1996957361 @default.
• W2005123729 cites W1997675153 @default.
• W2005123729 cites W2000183149 @default.
• W2005123729 cites W2001008169 @default.
• W2005123729 cites W2001411045 @default.
• W2005123729 cites W2004227588 @default.
• W2005123729 cites W2005416094 @default.
• W2005123729 cites W2007919092 @default.
• W2005123729 cites W2008782354 @default.
• W2005123729 cites W2010142606 @default.
• W2005123729 cites W2012180839 @default.
• W2005123729 cites W2012391532 @default.
• W2005123729 cites W201657286 @default.
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• W2005123729 cites W2027778502 @default.
• W2005123729 cites W2031803626 @default.
• W2005123729 cites W2032827821 @default.
• W2005123729 cites W2037831767 @default.
• W2005123729 cites W2045622329 @default.
• W2005123729 cites W2049896656 @default.
• W2005123729 cites W2050364102 @default.
• W2005123729 cites W2050442066 @default.
• W2005123729 cites W2051988666 @default.
• W2005123729 cites W2064813976 @default.
• W2005123729 cites W2065874893 @default.
• W2005123729 cites W2066690075 @default.
• W2005123729 cites W2067981937 @default.
• W2005123729 cites W2068993393 @default.
• W2005123729 cites W2079497611 @default.
• W2005123729 cites W2080882866 @default.
• W2005123729 cites W2083116048 @default.
• W2005123729 cites W2083338331 @default.
• W2005123729 cites W2085798719 @default.
• W2005123729 cites W2086576026 @default.
• W2005123729 cites W2086787762 @default.
• W2005123729 cites W2086853339 @default.
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• W2005123729 cites W2098877379 @default.
• W2005123729 cites W2106099541 @default.
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• W2005123729 cites W2147888023 @default.
• W2005123729 cites W2156434383 @default.
• W2005123729 cites W2161396786 @default.
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• W2005123729 doi "https://doi.org/10.1093/molbev/msh050" @default.
• W2005123729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14694081" @default.
• W2005123729 hasPublicationYear "2004" @default.
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