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• W2005125005 abstract "Sodium salicylate is an inexpensive, readily available anti-inflammatory agent which inhibits NF-κB in in vitro models. We examined whether it was possible to safely achieve and maintain salicylate levels known to inhibit NF-κB in vitro in 11 patients with MDS or AML taking sodium salicylate. Most patients achieved the target blood salicylate level (20–30 mg/dL) with acceptable toxicity, including reversible grade 1/2 elevations of hepatic transaminases (n = 4) and ototoxicity (n = 4). One patient had grade 3/4 elevations in AST/ALT. This study suggests that sodium salicylate may be safely combined with conventional chemotherapy regimens which are not associated with significant ototoxicity or hepatotoxicity." @default.
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• W2005125005 date "2012-05-01" @default.
• W2005125005 modified "2023-09-24" @default.
• W2005125005 title "Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia" @default.
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• W2005125005 doi "https://doi.org/10.1016/j.leukres.2011.10.023" @default.
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