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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005127154> ?p ?o ?g. }

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• W2005127154 abstract "The bioassay-guided fractionation of stems from Kielmeyera variabilis, traditionally used in Brazilian folk medicine, yielded assiguxanthone-B (1), kielcorin (4), 2,5-dihydroxybenzoic acid (3), and a mixture of xanthones containing assiguxanthone-B (1) and 1,3,5,6-tetrahydroxy-2-prenylxanthone (2) (1:1 w/w). The xanthone mixture inhibited Staphylococcus aureus and Bacillus subtilis at a concentration of 6.25 g/ml. When tested alone, the minimal inhibitory concentration of assiguxanthone-B was 25 g/ml against B. subtilis. Kielcorin and 2,5-dihydroxybenzoic acid were inactive against both strains. None of the fractions was active against Escherichia coli or Pseudomonas aeruginosa. Viable cells of S. aureus were reduced by a 1-3 log CFU/ml within 12 h after exposure of one to eight times the MIC of the xanthone mixture. It is not known whether the tetrahydroxy-2-prenylxanthone or other components of the xanthone mixture are responsible for the main antibacterial activity or whether additive or synergistic action is involved" @default.
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• W2005127154 date "2003-06-01" @default.
• W2005127154 modified "2023-10-16" @default.
• W2005127154 title "Antibacterial xanthones from Kielmeyera variabilis mart. (Clusiaceae)" @default.
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• W2005127154 doi "https://doi.org/10.1590/s0074-02762003000400023" @default.
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