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- W2005128454 abstract "The depression of Vmax of the action potential in guinea-pig ventricular muscle by aprindine and quanidine was compared. Aprindine caused a more pronounced rate-dependent block (Kd = 10(-6) M at 3.3 Hz) than did quinidine (Kd = 1.6 X 10(-5) M at 3.3 Hz). Aprindine shifted the relationship between Vmax and resting potential to a more negative potential (mean 9.2 mV: 10 microM) than did quinidine (mean 5.7 mV: 10 microM). In addition, aprindine caused a more pronounced resting block (Kd = 1.3 X 10(-5) M) than quinidine (Kd = 8.6 X 10(-5) M). It is concluded that aprindine has a higher affinity for activated and/or inactivated and resting state channels than quinidine, making channels unavailable for conduction upon activation." @default.
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- W2005128454 date "1988-08-01" @default.
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- W2005128454 title "Comparative study of the block of Vmax by aprindine and quinidine in the guinea-pig heart muscle" @default.
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- W2005128454 doi "https://doi.org/10.1016/0014-2999(88)90616-4" @default.
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