FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005129085> ?p ?o ?g. }

• W2005129085 endingPage "74" @default.
• W2005129085 startingPage "66" @default.
• W2005129085 abstract "Peripheral neuropathy has been associated with structural and functional changes of the amygdala, a key player in emotions. Here we study whether peripheral neuropathy influences pain regulation by the amygdala. For this purpose, we determined discharge rates of presumably pro- and antinociceptive pain-regulatory neurons in the rostral ventromedial medulla (RVM) following microinjection of various glutamatergic compounds into the central nucleus of the amygdala. RVM neurons were recorded in pentobarbitone-anesthetized rats with a peripheral nerve injury or sham-operation. In a separate behavioral experiment, we determined whether the influence of amygdaloid administration of a glutamatergic compound on affective pain-related behavior, as assessed by an aversive place-conditioning test, is changed by neuropathy. While glutamate or an NMDA receptor antagonist in the amygdala failed to induce marked changes in discharge rates of RVM cells, amygdaloid administration of DHPG, a group I metabotropic glutamate receptor (mGluR) agonist acting on mGluR(1) and mGluR(5), increased discharge rates of presumably pronociceptive RVM ON-cells in nerve-injured but not sham-operated animals. This pronociceptive effect of DHPG was reversed by MPEP (mGluR(5) antagonist) and CPCCOEt (mGluR(1) antagonist). CHPG, an mGluR(5) agonist, failed to influence ON-cell activity and DHPG failed to influence activity of presumably antinociceptive RVM OFF-cells. Amygdaloid administration of DHPG increased and that of CPCCOEt decreased affective pain-related behavior in nerve-injured animals. The results suggest that following nerve injury, the amygdaloid group I mGluR, particularly subtype mGluR(1), has an enhanced pronociceptive effect providing a potential mechanism for emotional enhancement of pain in peripheral neuropathy." @default.
• W2005129085 created "2016-06-24" @default.
• W2005129085 creator A5005184266 @default.
• W2005129085 creator A5043618203 @default.
• W2005129085 creator A5079208975 @default.
• W2005129085 creator A5085760992 @default.
• W2005129085 date "2009-03-01" @default.
• W2005129085 modified "2023-10-16" @default.
• W2005129085 title "Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals" @default.
• W2005129085 cites W1534340867 @default.
• W2005129085 cites W1548308975 @default.
• W2005129085 cites W1761628643 @default.
• W2005129085 cites W1965066118 @default.
• W2005129085 cites W1965981014 @default.
• W2005129085 cites W1972220137 @default.
• W2005129085 cites W1982422119 @default.
• W2005129085 cites W1983257841 @default.
• W2005129085 cites W1992680065 @default.
• W2005129085 cites W1993267237 @default.
• W2005129085 cites W1998616390 @default.
• W2005129085 cites W2002664363 @default.
• W2005129085 cites W2003549933 @default.
• W2005129085 cites W2004803198 @default.
• W2005129085 cites W2018644390 @default.
• W2005129085 cites W2024136403 @default.
• W2005129085 cites W2027072793 @default.
• W2005129085 cites W2027403654 @default.
• W2005129085 cites W2027523863 @default.
• W2005129085 cites W2041632921 @default.
• W2005129085 cites W2041676962 @default.
• W2005129085 cites W2047010161 @default.
• W2005129085 cites W2050251142 @default.
• W2005129085 cites W2071265938 @default.
• W2005129085 cites W2080729533 @default.
• W2005129085 cites W2093090171 @default.
• W2005129085 cites W2095577553 @default.
• W2005129085 cites W2107797364 @default.
• W2005129085 cites W2114501436 @default.
• W2005129085 cites W2117693696 @default.
• W2005129085 cites W2125079193 @default.
• W2005129085 cites W2126238465 @default.
• W2005129085 cites W2136876344 @default.
• W2005129085 cites W2141901630 @default.
• W2005129085 cites W2143532600 @default.
• W2005129085 cites W2143573423 @default.
• W2005129085 cites W2144933081 @default.
• W2005129085 cites W2154546113 @default.
• W2005129085 cites W2157473071 @default.
• W2005129085 cites W2162149333 @default.
• W2005129085 cites W4251547781 @default.
• W2005129085 doi "https://doi.org/10.1016/j.expneurol.2008.11.005" @default.
• W2005129085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19094988" @default.
• W2005129085 hasPublicationYear "2009" @default.
• W2005129085 type Work @default.
• W2005129085 sameAs 2005129085 @default.
• W2005129085 citedByCount "39" @default.
• W2005129085 countsByYear W20051290852012 @default.
• W2005129085 countsByYear W20051290852013 @default.
• W2005129085 countsByYear W20051290852014 @default.
• W2005129085 countsByYear W20051290852015 @default.
• W2005129085 countsByYear W20051290852016 @default.
• W2005129085 countsByYear W20051290852017 @default.
• W2005129085 countsByYear W20051290852018 @default.
• W2005129085 countsByYear W20051290852019 @default.
• W2005129085 countsByYear W20051290852020 @default.
• W2005129085 countsByYear W20051290852021 @default.
• W2005129085 countsByYear W20051290852022 @default.
• W2005129085 crossrefType "journal-article" @default.
• W2005129085 hasAuthorship W2005129085A5005184266 @default.
• W2005129085 hasAuthorship W2005129085A5043618203 @default.
• W2005129085 hasAuthorship W2005129085A5079208975 @default.
• W2005129085 hasAuthorship W2005129085A5085760992 @default.
• W2005129085 hasBestOaLocation W20051290852 @default.
• W2005129085 hasConcept C126322002 @default.
• W2005129085 hasConcept C15490471 @default.
• W2005129085 hasConcept C15744967 @default.
• W2005129085 hasConcept C169760540 @default.
• W2005129085 hasConcept C170493617 @default.
• W2005129085 hasConcept C207951395 @default.
• W2005129085 hasConcept C2776885963 @default.
• W2005129085 hasConcept C2777659854 @default.
• W2005129085 hasConcept C2778938600 @default.
• W2005129085 hasConcept C2779144063 @default.
• W2005129085 hasConcept C2779245659 @default.
• W2005129085 hasConcept C2780648746 @default.
• W2005129085 hasConcept C41653306 @default.
• W2005129085 hasConcept C42219234 @default.
• W2005129085 hasConcept C49051014 @default.
• W2005129085 hasConcept C61174792 @default.
• W2005129085 hasConcept C71924100 @default.
• W2005129085 hasConcept C98274493 @default.
• W2005129085 hasConceptScore W2005129085C126322002 @default.
• W2005129085 hasConceptScore W2005129085C15490471 @default.
• W2005129085 hasConceptScore W2005129085C15744967 @default.
• W2005129085 hasConceptScore W2005129085C169760540 @default.
• W2005129085 hasConceptScore W2005129085C170493617 @default.
• W2005129085 hasConceptScore W2005129085C207951395 @default.
• W2005129085 hasConceptScore W2005129085C2776885963 @default.

• next