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- W2005129328 abstract "The diagnosis of tumour progression or progressive disease (PD) is a key element for designing and interpreting contemporary phase II trials. In some cases, PD is stated by the physician and is not formally confirmed by imaging.In this study, we intend to analyze the value of the PD based on clinical judgment and the risk of overestimating the occurrence of PD by clinical judgment.We have conducted a single-centre retrospective study to analyse the diagnostic accuracy of this clinical judgment compared to planned imaging including all patients enrolled in our institution in phase II trials investigating systemic treatments for advanced solid tumours between January 2008 and November 2010.The positive predictive value (PPV) and the specificity of clinical judgment of PD was very high (>90%).According to this study, the clinical judgment of PD is highly predictive of radiological PD as assessed, for example, by RECIST. Physicians do not overestimate PD occurence. Clinical judgment of PD could be taken into account in the definition of PD." @default.
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- W2005129328 date "2012-12-26" @default.
- W2005129328 modified "2023-10-16" @default.
- W2005129328 title "Predictive Value of Clinical Judgment of Tumour Progression in Phase II Trials" @default.
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- W2005129328 doi "https://doi.org/10.1371/journal.pone.0052638" @default.
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