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- W2005137415 abstract "An estimated 182,640 women and 1,990 men were diagnosed with breast cancer in 2008, and approximately 40,480 women and 450 men died from the disease ( 1 ). Thus, continued mechanistic studies are needed to understand the causes and develop additional therapeutics for this complicated disease. The MCF-7 cell system is one of the most recognized models for estrogen receptor (ER)-positive breast cancer and has generated ~13,000 publications cited in PubMed to date. A number of clues for biological mechanisms related to apoptotic/anti-apoptotic pathways and chemoresistance were elucidated and summarized in our previous review ( 2 ). The focus of this review is new knowledge of the central role of sphingolipid signaling in apoptotic mechanisms in estrogen receptor-positive breast cancer. The ultimate goal is to target crucial steps in survival signaling pathways that may ultimately provide additional translational solutions to the successful pharmacologic treatment of breast cancer." @default.
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- W2005137415 date "2009-11-01" @default.
- W2005137415 modified "2023-10-18" @default.
- W2005137415 title "Sphingolipids as Determinants of Apoptosis and Chemoresistance in the MCF-7 Cell Model System" @default.
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- W2005137415 doi "https://doi.org/10.3181/0902-mr-77" @default.
- W2005137415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19546354" @default.
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