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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005141847> ?p ?o ?g. }

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• W2005141847 abstract "<i>Objectives:</i> Cdc4 (Fbxw7) is a potential tumor suppressor that regulates ubiquitination and proteolysis of multiple targets such as cyclin E, <i>c-Myc</i>, <i>c-Jun</i> and Notch. <i>CDC4</i> mutations were investigated in 194 colorectal carcinomas and adenomas for comparison between sporadic and hereditary cancers. <i>Methods:</i> Mutations of the <i>CDC4</i> gene were analyzed by PCR-SSCP and sequencing, and loss of heterozygosity (LOH) was analyzed by microsatellite marker analysis. <i>Results:</i> Somatic <i>CDC4</i> mutations were detected in 9% (3 of 33) of hereditary nonpolyposis colorectal cancer (HNPCC), 9% (3 of 33) of familial adenomatous polyposis (FAP) carcinomas, and 10% (7 of 73) of sporadic carcinomas. <i>CDC4</i> mutations were also detected in adenomas at frequencies of 6% (2 of 31) and 4% (1 of 24) in FAP and sporadic cases, respectively. Frameshift mutations were observed in HNPCC tumors, while single-base substitutions predominantly occurred in FAP and sporadic tumors. LOH at the chromosome 4q region was rarely detected in tumors with <i>CDC4</i> mutations. <i>Conclusions:</i> The results indicate that the frequency of <i>CDC4</i> mutations in colorectal tumors is similar in patients with HNPCC and FAP compared to patients with sporadic carcinomas. Moreover, infrequent LOH suggests that the <i>CDC4</i> gene does not follow the general 2-hit model." @default.
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• W2005141847 date "2009-01-01" @default.
• W2005141847 modified "2023-10-16" @default.
• W2005141847 title "Somatic Mutations of the <i>CDC4 (FBXW7)</i> Gene in Hereditary Colorectal Tumors" @default.
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• W2005141847 doi "https://doi.org/10.1159/000217811" @default.
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