Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005142405> ?p ?o ?g. }
- W2005142405 endingPage "356" @default.
- W2005142405 startingPage "347" @default.
- W2005142405 abstract "Accidental exposure by inhalation to alpha-emitting particles from mixed oxide (MOX: uranium and plutonium oxide) fuels is a potential long-term health risk to workers in nuclear fuel fabrication plants. For MOX fuels, the risk of lung cancer development may be different from that assigned to individual components (plutonium, uranium) given different physico-chemical characteristics. The objective of this study was to investigate late effects in rat lungs following inhalation of MOX aerosols of similar particle size containing 2.5 or 7.1% plutonium. Conscious rats were exposed to MOX aerosols and kept for their entire lifespan. Different initial lung burdens (ILBs) were obtained using different amounts of MOX. Lung total alpha activity was determined by external counting and at autopsy for total lung dose calculation. Fixed lung tissue was used for anatomopathological, autoradiographical, and immunohistochemical analyses. Inhalation of MOX at ILBs ranging from 1–20 kBq resulted in lung pathologies (90% of rats) including fibrosis (70%) and malignant lung tumors (45%). High ILBs (4–20 kBq) resulted in reduced survival time (N = 102; p < 0.05) frequently associated with lung fibrosis. Malignant tumor incidence increased linearly with dose (up to 60 Gy) with a risk of 1–1.6% Gy−1 for MOX, similar to results for industrial plutonium oxide alone (1.9% Gy−1). Staining with antibodies against Surfactant Protein-C, Thyroid Transcription Factor-1, or Oct-4 showed differential labeling of tumor types. In conclusion, late effects following MOX inhalation result in similar risk for development of lung tumors as compared with industrial plutonium oxide." @default.
- W2005142405 created "2016-06-24" @default.
- W2005142405 creator A5021250954 @default.
- W2005142405 creator A5023068133 @default.
- W2005142405 creator A5027064010 @default.
- W2005142405 creator A5055496572 @default.
- W2005142405 creator A5081172544 @default.
- W2005142405 creator A5083609031 @default.
- W2005142405 date "2010-09-01" @default.
- W2005142405 modified "2023-10-01" @default.
- W2005142405 title "LATE-OCCURRING PULMONARY PATHOLOGIES FOLLOWING INHALATION OF MIXED OXIDE (URANIUM + PLUTONIUM OXIDE) AEROSOL IN THE RAT" @default.
- W2005142405 cites W1972126971 @default.
- W2005142405 cites W1977898297 @default.
- W2005142405 cites W1982580620 @default.
- W2005142405 cites W1986043499 @default.
- W2005142405 cites W1987362277 @default.
- W2005142405 cites W1989169845 @default.
- W2005142405 cites W1993612735 @default.
- W2005142405 cites W1997046409 @default.
- W2005142405 cites W2006719016 @default.
- W2005142405 cites W2011805937 @default.
- W2005142405 cites W2013614359 @default.
- W2005142405 cites W2015620348 @default.
- W2005142405 cites W2016024575 @default.
- W2005142405 cites W2019902979 @default.
- W2005142405 cites W2031334634 @default.
- W2005142405 cites W2036791461 @default.
- W2005142405 cites W2044224678 @default.
- W2005142405 cites W2046812753 @default.
- W2005142405 cites W2052201562 @default.
- W2005142405 cites W2062702806 @default.
- W2005142405 cites W2064119928 @default.
- W2005142405 cites W2066516462 @default.
- W2005142405 cites W2073073930 @default.
- W2005142405 cites W2075900070 @default.
- W2005142405 cites W2076044667 @default.
- W2005142405 cites W2076948526 @default.
- W2005142405 cites W2081723025 @default.
- W2005142405 cites W2084735696 @default.
- W2005142405 cites W2089384439 @default.
- W2005142405 cites W2098509330 @default.
- W2005142405 cites W2104209176 @default.
- W2005142405 cites W2104959917 @default.
- W2005142405 cites W2105902643 @default.
- W2005142405 cites W2107308900 @default.
- W2005142405 cites W2112075119 @default.
- W2005142405 cites W2125605297 @default.
- W2005142405 cites W2136396951 @default.
- W2005142405 cites W2136940597 @default.
- W2005142405 cites W2168661021 @default.
- W2005142405 cites W2302268991 @default.
- W2005142405 cites W4300722992 @default.
- W2005142405 cites W4301000131 @default.
- W2005142405 doi "https://doi.org/10.1097/hp.0b013e3181c75750" @default.
- W2005142405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20699696" @default.
- W2005142405 hasPublicationYear "2010" @default.
- W2005142405 type Work @default.
- W2005142405 sameAs 2005142405 @default.
- W2005142405 citedByCount "7" @default.
- W2005142405 countsByYear W20051424052012 @default.
- W2005142405 countsByYear W20051424052014 @default.
- W2005142405 countsByYear W20051424052016 @default.
- W2005142405 countsByYear W20051424052019 @default.
- W2005142405 countsByYear W20051424052021 @default.
- W2005142405 crossrefType "journal-article" @default.
- W2005142405 hasAuthorship W2005142405A5021250954 @default.
- W2005142405 hasAuthorship W2005142405A5023068133 @default.
- W2005142405 hasAuthorship W2005142405A5027064010 @default.
- W2005142405 hasAuthorship W2005142405A5055496572 @default.
- W2005142405 hasAuthorship W2005142405A5081172544 @default.
- W2005142405 hasAuthorship W2005142405A5083609031 @default.
- W2005142405 hasConcept C126322002 @default.
- W2005142405 hasConcept C142724271 @default.
- W2005142405 hasConcept C177322064 @default.
- W2005142405 hasConcept C185592680 @default.
- W2005142405 hasConcept C2776256026 @default.
- W2005142405 hasConcept C2776954882 @default.
- W2005142405 hasConcept C2777714996 @default.
- W2005142405 hasConcept C2779777708 @default.
- W2005142405 hasConcept C2989005 @default.
- W2005142405 hasConcept C42219234 @default.
- W2005142405 hasConcept C540271850 @default.
- W2005142405 hasConcept C71924100 @default.
- W2005142405 hasConcept C8138999 @default.
- W2005142405 hasConcept C82085835 @default.
- W2005142405 hasConceptScore W2005142405C126322002 @default.
- W2005142405 hasConceptScore W2005142405C142724271 @default.
- W2005142405 hasConceptScore W2005142405C177322064 @default.
- W2005142405 hasConceptScore W2005142405C185592680 @default.
- W2005142405 hasConceptScore W2005142405C2776256026 @default.
- W2005142405 hasConceptScore W2005142405C2776954882 @default.
- W2005142405 hasConceptScore W2005142405C2777714996 @default.
- W2005142405 hasConceptScore W2005142405C2779777708 @default.
- W2005142405 hasConceptScore W2005142405C2989005 @default.
- W2005142405 hasConceptScore W2005142405C42219234 @default.
- W2005142405 hasConceptScore W2005142405C540271850 @default.
- W2005142405 hasConceptScore W2005142405C71924100 @default.
- W2005142405 hasConceptScore W2005142405C8138999 @default.