Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005146092> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2005146092 endingPage "590" @default.
- W2005146092 startingPage "587" @default.
- W2005146092 abstract ": Since the radiosensitizing effect of KU-2285 at relatively low dose levels is not known, we investigated its efficacy at such low concentrations or doses achievable in humans with oral administration of 0.3–1.0 g/m2. : KU-2285 was tested in comparison with SR-2508 at low concentrations (0.05–0.25 mM) in vitro by the cytokinesis-block micronucleus assay and by the colony formation assay, and at low drug doses (12.5–50 mg/kg) in vivo by the in vivo-in vitro assay and by the growth delay assay using SCC VII tumors in C3H/He mice. : In the cytokinesis-block micronucleus assay, the sensitizer enhancement ratio (SER) for KU-2285 and SR-2508 was 1.43 and 1.17 at 0.05 mM, 1.75 and 1.27 at 0.10 mM, and 2.14 and 1.69 at 0.25 mM, respectively. In the colony formation assay, the SER for KU-2285 was also greater than that for SR-2508. In the in vivo-in vitro assay, the SER for KU-2285 and SR-2508 was 1.11 and 1.04 at 12.5 mg/kg, 1.21 and 1.04 at 25 mg/kg, and 1.26 and 1.18 at 50 mg/kg, respectively. In the growth delay assay at 50 mg/kg, no tumor regrowth was observed in four of the 18 mice treated with KU-2285 + 25 Gy, although the growth delay time for the remaining mice was similar to that for SR-2508 + 25 Gy. : KU-2285 was more effective than SR-2508 both at low drug concentrations in vitro and at low drug doses in vivo. These promising findings suggest the potential superiority of KU-2285 over SR-2508 as a radiosensitizer for clinical use." @default.
- W2005146092 created "2016-06-24" @default.
- W2005146092 creator A5013307791 @default.
- W2005146092 creator A5040691530 @default.
- W2005146092 creator A5050452238 @default.
- W2005146092 creator A5054458732 @default.
- W2005146092 creator A5071240286 @default.
- W2005146092 creator A5078435301 @default.
- W2005146092 creator A5084833714 @default.
- W2005146092 date "1994-06-01" @default.
- W2005146092 modified "2023-09-27" @default.
- W2005146092 title "Comparison of radiosensitizing effect of KU-2285 and SR-2508 at low drug concentrations and doses" @default.
- W2005146092 cites W1978544089 @default.
- W2005146092 cites W1993642626 @default.
- W2005146092 cites W1994555849 @default.
- W2005146092 cites W2045658902 @default.
- W2005146092 cites W2051567532 @default.
- W2005146092 cites W2059232606 @default.
- W2005146092 cites W2066082960 @default.
- W2005146092 cites W2085851177 @default.
- W2005146092 cites W2088561350 @default.
- W2005146092 cites W2090392139 @default.
- W2005146092 cites W2097813123 @default.
- W2005146092 cites W2330695030 @default.
- W2005146092 doi "https://doi.org/10.1016/0360-3016(94)90462-6" @default.
- W2005146092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8005820" @default.
- W2005146092 hasPublicationYear "1994" @default.
- W2005146092 type Work @default.
- W2005146092 sameAs 2005146092 @default.
- W2005146092 citedByCount "9" @default.
- W2005146092 countsByYear W20051460922019 @default.
- W2005146092 crossrefType "journal-article" @default.
- W2005146092 hasAuthorship W2005146092A5013307791 @default.
- W2005146092 hasAuthorship W2005146092A5040691530 @default.
- W2005146092 hasAuthorship W2005146092A5050452238 @default.
- W2005146092 hasAuthorship W2005146092A5054458732 @default.
- W2005146092 hasAuthorship W2005146092A5071240286 @default.
- W2005146092 hasAuthorship W2005146092A5078435301 @default.
- W2005146092 hasAuthorship W2005146092A5084833714 @default.
- W2005146092 hasConcept C126322002 @default.
- W2005146092 hasConcept C150903083 @default.
- W2005146092 hasConcept C16685009 @default.
- W2005146092 hasConcept C202751555 @default.
- W2005146092 hasConcept C207001950 @default.
- W2005146092 hasConcept C29730261 @default.
- W2005146092 hasConcept C45080847 @default.
- W2005146092 hasConcept C55493867 @default.
- W2005146092 hasConcept C71924100 @default.
- W2005146092 hasConcept C86803240 @default.
- W2005146092 hasConceptScore W2005146092C126322002 @default.
- W2005146092 hasConceptScore W2005146092C150903083 @default.
- W2005146092 hasConceptScore W2005146092C16685009 @default.
- W2005146092 hasConceptScore W2005146092C202751555 @default.
- W2005146092 hasConceptScore W2005146092C207001950 @default.
- W2005146092 hasConceptScore W2005146092C29730261 @default.
- W2005146092 hasConceptScore W2005146092C45080847 @default.
- W2005146092 hasConceptScore W2005146092C55493867 @default.
- W2005146092 hasConceptScore W2005146092C71924100 @default.
- W2005146092 hasConceptScore W2005146092C86803240 @default.
- W2005146092 hasIssue "3" @default.
- W2005146092 hasLocation W20051460921 @default.
- W2005146092 hasLocation W20051460922 @default.
- W2005146092 hasOpenAccess W2005146092 @default.
- W2005146092 hasPrimaryLocation W20051460921 @default.
- W2005146092 hasRelatedWork W1486362009 @default.
- W2005146092 hasRelatedWork W1964487184 @default.
- W2005146092 hasRelatedWork W1966224786 @default.
- W2005146092 hasRelatedWork W1994126425 @default.
- W2005146092 hasRelatedWork W1997868327 @default.
- W2005146092 hasRelatedWork W2067201962 @default.
- W2005146092 hasRelatedWork W2109033587 @default.
- W2005146092 hasRelatedWork W2401353669 @default.
- W2005146092 hasRelatedWork W2806494979 @default.
- W2005146092 hasRelatedWork W2993094670 @default.
- W2005146092 hasVolume "29" @default.
- W2005146092 isParatext "false" @default.
- W2005146092 isRetracted "false" @default.
- W2005146092 magId "2005146092" @default.
- W2005146092 workType "article" @default.