Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005151284> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2005151284 endingPage "1169" @default.
- W2005151284 startingPage "1165" @default.
- W2005151284 abstract "This open-label study was conducted as a preliminary assessment of rifaximin (200 mg TID for 16 weeks) for the treatment of active Crohn's disease in patients (n = 29) with symptoms for at least 3 months before screening and a Crohn's Disease Activity Index (CDAI) score > 220 and < 400.At the end of month 4, mean +/- CDAI score was reduced by 43% compared with baseline in the intent-to-treat population (n = 29; baseline = 278 +/- 51; month 4 = 159 +/- 102; p < 0.0001 month 4 versus baseline). A similar pattern of results was observed in the per-protocol population (i.e., patients at least 70% compliant with the treatment regimen and having no protocol violations thought to affect efficacy results; n = 16), in which mean CDAI scores at month 4 were reduced by 41% from a baseline of 262.9 +/- 38.2 to 155.6 +/- 104.5 (p = 0.0009 month 4 versus baseline). Fifty-nine percent of patients (59%) had a > or = 70-point improvement in CDAI score beginning with the first assessment at the end of month 1. By the end of the treatment period, 78% of patients had a > or = 70-point improvement in CDAI score. Clinical remission, defined as CDAI score < 150, was observed at the end of treatment months 1, 2, 3, and 4 in 41%, 56%, 56%, and 59% of patients, respectively. Twenty-three (23) patients completed the 4-month course of rifaximin therapy, and 6 prematurely withdrew. The most common adverse events were abdominal pain, fatigue, and headache.These data, which are consistent with the possibility that rifaximin may be useful for active Crohn's disease, warrant confirmation in a randomized, double-blind, placebo-controlled trial." @default.
- W2005151284 created "2016-06-24" @default.
- W2005151284 creator A5001863700 @default.
- W2005151284 creator A5075215868 @default.
- W2005151284 date "2005-06-24" @default.
- W2005151284 modified "2023-09-27" @default.
- W2005151284 title "An open-label evaluation of rifaximin in the treatment of active Crohn's disease" @default.
- W2005151284 cites W1706367474 @default.
- W2005151284 cites W1989307048 @default.
- W2005151284 cites W1995417009 @default.
- W2005151284 cites W2010459511 @default.
- W2005151284 cites W2020439913 @default.
- W2005151284 cites W2022507641 @default.
- W2005151284 cites W2037505052 @default.
- W2005151284 cites W2045466789 @default.
- W2005151284 cites W2054404048 @default.
- W2005151284 cites W2055423211 @default.
- W2005151284 cites W2096008599 @default.
- W2005151284 cites W2131727319 @default.
- W2005151284 cites W2136419595 @default.
- W2005151284 cites W3149527659 @default.
- W2005151284 cites W40466275 @default.
- W2005151284 cites W4292198229 @default.
- W2005151284 doi "https://doi.org/10.1185/030079905x53252" @default.
- W2005151284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16083525" @default.
- W2005151284 hasPublicationYear "2005" @default.
- W2005151284 type Work @default.
- W2005151284 sameAs 2005151284 @default.
- W2005151284 citedByCount "64" @default.
- W2005151284 countsByYear W20051512842012 @default.
- W2005151284 countsByYear W20051512842013 @default.
- W2005151284 countsByYear W20051512842015 @default.
- W2005151284 countsByYear W20051512842016 @default.
- W2005151284 countsByYear W20051512842017 @default.
- W2005151284 countsByYear W20051512842018 @default.
- W2005151284 countsByYear W20051512842019 @default.
- W2005151284 countsByYear W20051512842020 @default.
- W2005151284 countsByYear W20051512842021 @default.
- W2005151284 countsByYear W20051512842022 @default.
- W2005151284 crossrefType "journal-article" @default.
- W2005151284 hasAuthorship W2005151284A5001863700 @default.
- W2005151284 hasAuthorship W2005151284A5075215868 @default.
- W2005151284 hasConcept C126322002 @default.
- W2005151284 hasConcept C168563851 @default.
- W2005151284 hasConcept C197934379 @default.
- W2005151284 hasConcept C203092338 @default.
- W2005151284 hasConcept C2778889925 @default.
- W2005151284 hasConcept C2779134260 @default.
- W2005151284 hasConcept C2779280984 @default.
- W2005151284 hasConcept C2780955771 @default.
- W2005151284 hasConcept C2781413609 @default.
- W2005151284 hasConcept C2908647359 @default.
- W2005151284 hasConcept C501593827 @default.
- W2005151284 hasConcept C71924100 @default.
- W2005151284 hasConcept C86803240 @default.
- W2005151284 hasConcept C89423630 @default.
- W2005151284 hasConcept C99454951 @default.
- W2005151284 hasConceptScore W2005151284C126322002 @default.
- W2005151284 hasConceptScore W2005151284C168563851 @default.
- W2005151284 hasConceptScore W2005151284C197934379 @default.
- W2005151284 hasConceptScore W2005151284C203092338 @default.
- W2005151284 hasConceptScore W2005151284C2778889925 @default.
- W2005151284 hasConceptScore W2005151284C2779134260 @default.
- W2005151284 hasConceptScore W2005151284C2779280984 @default.
- W2005151284 hasConceptScore W2005151284C2780955771 @default.
- W2005151284 hasConceptScore W2005151284C2781413609 @default.
- W2005151284 hasConceptScore W2005151284C2908647359 @default.
- W2005151284 hasConceptScore W2005151284C501593827 @default.
- W2005151284 hasConceptScore W2005151284C71924100 @default.
- W2005151284 hasConceptScore W2005151284C86803240 @default.
- W2005151284 hasConceptScore W2005151284C89423630 @default.
- W2005151284 hasConceptScore W2005151284C99454951 @default.
- W2005151284 hasIssue "8" @default.
- W2005151284 hasLocation W20051512841 @default.
- W2005151284 hasLocation W20051512842 @default.
- W2005151284 hasOpenAccess W2005151284 @default.
- W2005151284 hasPrimaryLocation W20051512841 @default.
- W2005151284 hasRelatedWork W1761487289 @default.
- W2005151284 hasRelatedWork W1997244387 @default.
- W2005151284 hasRelatedWork W2083583084 @default.
- W2005151284 hasRelatedWork W2307753277 @default.
- W2005151284 hasRelatedWork W2387726705 @default.
- W2005151284 hasRelatedWork W2800662968 @default.
- W2005151284 hasRelatedWork W3081516035 @default.
- W2005151284 hasRelatedWork W3162394479 @default.
- W2005151284 hasRelatedWork W3212096909 @default.
- W2005151284 hasRelatedWork W4308976353 @default.
- W2005151284 hasVolume "21" @default.
- W2005151284 isParatext "false" @default.
- W2005151284 isRetracted "false" @default.
- W2005151284 magId "2005151284" @default.
- W2005151284 workType "article" @default.