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- W2005154791 abstract "Widespread use of third-generation cephalosporins appears to have selected cephalosporin-resistant pneumococci associated with the failure of these agents in the management of meningitis. Breakpoints of 0.5 mg/l for intermediate and 2 mg/l for full resistance are proposed for the treatment of pneumococcal meningitis. As no disc tests reliably identify these breakpoints, MIC or E test confirmation of third-generation cephalosporin resistance is recommended for all strains found resistant to a 1 mug oxacillin disk. Resistant strains can be selected in a single transformation event, with PBP 2X gene rearrangements conferring low level resistance and PBP 1A gene rearrangements conferring full resistance." @default.
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- W2005154791 title "Pneumococcal resistance to the third-generation cephalosporins: clinical, laboratory and molecular aspects" @default.
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- W2005154791 doi "https://doi.org/10.1016/0924-8579(94)90063-9" @default.
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