Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005164390> ?p ?o ?g. }
- W2005164390 endingPage "7" @default.
- W2005164390 startingPage "1" @default.
- W2005164390 abstract "There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy. These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells. Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector. We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector. Additionally, the sensitivity of the Timepix detector to monitor variations in tumour uptake based on the necrotic tissue volume was also studied. Compartmental analysis model was used, based on the obtained imaging data, to assess the Th-227 uptake. Results show that alpha particle, photon, electron, and muon tracks were detected and resolved by Timepix detector. The current study demonstrated that individual alpha particle emissions, resulting from targeted alpha therapy, can be visualised and quantified using Timepix detector. Furthermore, the variations in the uptake based on the tumour necrotic volume have been observed with four times higher uptake for tumours pretreated with chemotherapy than for those without chemotherapy." @default.
- W2005164390 created "2016-06-24" @default.
- W2005164390 creator A5021075431 @default.
- W2005164390 creator A5027460327 @default.
- W2005164390 creator A5081765668 @default.
- W2005164390 creator A5083049134 @default.
- W2005164390 date "2015-01-01" @default.
- W2005164390 modified "2023-10-16" @default.
- W2005164390 title "Autoradiography Imaging in Targeted Alpha Therapy with Timepix Detector" @default.
- W2005164390 cites W1981815669 @default.
- W2005164390 cites W1986848782 @default.
- W2005164390 cites W1991763724 @default.
- W2005164390 cites W2031020334 @default.
- W2005164390 cites W2031906277 @default.
- W2005164390 cites W2051912646 @default.
- W2005164390 cites W2052020365 @default.
- W2005164390 cites W2057123841 @default.
- W2005164390 cites W2058078526 @default.
- W2005164390 cites W2081969012 @default.
- W2005164390 cites W2091630347 @default.
- W2005164390 cites W2110181735 @default.
- W2005164390 cites W2116865296 @default.
- W2005164390 cites W2143509756 @default.
- W2005164390 cites W2331885769 @default.
- W2005164390 doi "https://doi.org/10.1155/2015/612580" @default.
- W2005164390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4320936" @default.
- W2005164390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25688285" @default.
- W2005164390 hasPublicationYear "2015" @default.
- W2005164390 type Work @default.
- W2005164390 sameAs 2005164390 @default.
- W2005164390 citedByCount "11" @default.
- W2005164390 countsByYear W20051643902016 @default.
- W2005164390 countsByYear W20051643902017 @default.
- W2005164390 countsByYear W20051643902018 @default.
- W2005164390 countsByYear W20051643902019 @default.
- W2005164390 countsByYear W20051643902020 @default.
- W2005164390 countsByYear W20051643902022 @default.
- W2005164390 crossrefType "journal-article" @default.
- W2005164390 hasAuthorship W2005164390A5021075431 @default.
- W2005164390 hasAuthorship W2005164390A5027460327 @default.
- W2005164390 hasAuthorship W2005164390A5081765668 @default.
- W2005164390 hasAuthorship W2005164390A5083049134 @default.
- W2005164390 hasBestOaLocation W20051643901 @default.
- W2005164390 hasConcept C120665830 @default.
- W2005164390 hasConcept C121332964 @default.
- W2005164390 hasConcept C15744967 @default.
- W2005164390 hasConcept C159110408 @default.
- W2005164390 hasConcept C168834538 @default.
- W2005164390 hasConcept C185544564 @default.
- W2005164390 hasConcept C19417346 @default.
- W2005164390 hasConcept C2775936607 @default.
- W2005164390 hasConcept C2775944032 @default.
- W2005164390 hasConcept C2778418280 @default.
- W2005164390 hasConcept C2989005 @default.
- W2005164390 hasConcept C49453240 @default.
- W2005164390 hasConcept C64943373 @default.
- W2005164390 hasConcept C66385817 @default.
- W2005164390 hasConcept C71924100 @default.
- W2005164390 hasConcept C75088862 @default.
- W2005164390 hasConcept C94915269 @default.
- W2005164390 hasConceptScore W2005164390C120665830 @default.
- W2005164390 hasConceptScore W2005164390C121332964 @default.
- W2005164390 hasConceptScore W2005164390C15744967 @default.
- W2005164390 hasConceptScore W2005164390C159110408 @default.
- W2005164390 hasConceptScore W2005164390C168834538 @default.
- W2005164390 hasConceptScore W2005164390C185544564 @default.
- W2005164390 hasConceptScore W2005164390C19417346 @default.
- W2005164390 hasConceptScore W2005164390C2775936607 @default.
- W2005164390 hasConceptScore W2005164390C2775944032 @default.
- W2005164390 hasConceptScore W2005164390C2778418280 @default.
- W2005164390 hasConceptScore W2005164390C2989005 @default.
- W2005164390 hasConceptScore W2005164390C49453240 @default.
- W2005164390 hasConceptScore W2005164390C64943373 @default.
- W2005164390 hasConceptScore W2005164390C66385817 @default.
- W2005164390 hasConceptScore W2005164390C71924100 @default.
- W2005164390 hasConceptScore W2005164390C75088862 @default.
- W2005164390 hasConceptScore W2005164390C94915269 @default.
- W2005164390 hasLocation W20051643901 @default.
- W2005164390 hasLocation W20051643902 @default.
- W2005164390 hasLocation W20051643903 @default.
- W2005164390 hasLocation W20051643904 @default.
- W2005164390 hasLocation W20051643905 @default.
- W2005164390 hasOpenAccess W2005164390 @default.
- W2005164390 hasPrimaryLocation W20051643901 @default.
- W2005164390 hasRelatedWork W1673478143 @default.
- W2005164390 hasRelatedWork W1997579395 @default.
- W2005164390 hasRelatedWork W2000084032 @default.
- W2005164390 hasRelatedWork W2024404989 @default.
- W2005164390 hasRelatedWork W2045879768 @default.
- W2005164390 hasRelatedWork W2046831705 @default.
- W2005164390 hasRelatedWork W2091611604 @default.
- W2005164390 hasRelatedWork W2153997679 @default.
- W2005164390 hasRelatedWork W3100991041 @default.
- W2005164390 hasRelatedWork W1643828965 @default.
- W2005164390 hasVolume "2015" @default.
- W2005164390 isParatext "false" @default.
- W2005164390 isRetracted "false" @default.
- W2005164390 magId "2005164390" @default.