Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005169469> ?p ?o ?g. }
- W2005169469 endingPage "88" @default.
- W2005169469 startingPage "79" @default.
- W2005169469 abstract "The acute and chronic effects of tumour necrosis factor-alpha (TNF-alpha) on leptin production by human preadipocytes, differentiated preadipocytes, and mature adipocytes have been examined by competitive RT-PCR of leptin mRNA and by western blotting. In preadipocytes, secreted leptin was detectable after 5-day incubation in differentiation medium and this increased 4-fold by day 20. TNF-alpha blocked leptin synthesis during differentiation. In differentiated preadipocytes and mature adipocytes, TNF-alpha treatment resulted in time-dependent decreases in mRNA for leptin and glycerol-3-phosphate dehydrogenase (G3PD). In contrast, TNF-alpha (4-8-h treatment) resulted in a 4-fold increase in leptin release. This effect was lost at 24 h and leptin accumulation in culture medium was decreased 24-48 h after TNF-alpha addition. We conclude that TNF-alpha stimulates the release of preformed leptin from human mature adipocytes and existing differentiated preadipocytes, which may contribute to obesity/infection-linked hyperleptinemia, and that TNF-alpha inhibits leptin synthesis via inhibition of preadipocyte differentiation and induction of adipocyte dedifferentiation." @default.
- W2005169469 created "2016-06-24" @default.
- W2005169469 creator A5000424272 @default.
- W2005169469 creator A5009389483 @default.
- W2005169469 creator A5023295361 @default.
- W2005169469 creator A5086295953 @default.
- W2005169469 date "2000-01-01" @default.
- W2005169469 modified "2023-09-25" @default.
- W2005169469 title "Tumour necrosis factor-α exerts dual effects on human adipose leptin synthesis and release" @default.
- W2005169469 cites W1145363944 @default.
- W2005169469 cites W1597210981 @default.
- W2005169469 cites W1970825712 @default.
- W2005169469 cites W1973861293 @default.
- W2005169469 cites W1974033843 @default.
- W2005169469 cites W1988870963 @default.
- W2005169469 cites W1992848336 @default.
- W2005169469 cites W1993203791 @default.
- W2005169469 cites W1996713062 @default.
- W2005169469 cites W1999771650 @default.
- W2005169469 cites W2002165978 @default.
- W2005169469 cites W2013114215 @default.
- W2005169469 cites W2014444795 @default.
- W2005169469 cites W2021895570 @default.
- W2005169469 cites W2027297481 @default.
- W2005169469 cites W2035238675 @default.
- W2005169469 cites W2060682066 @default.
- W2005169469 cites W2063840236 @default.
- W2005169469 cites W2066160102 @default.
- W2005169469 cites W2075019242 @default.
- W2005169469 cites W2088443341 @default.
- W2005169469 cites W2093871599 @default.
- W2005169469 cites W2096299662 @default.
- W2005169469 cites W2101340193 @default.
- W2005169469 cites W2123753226 @default.
- W2005169469 cites W2129316761 @default.
- W2005169469 cites W2139465238 @default.
- W2005169469 cites W2143873575 @default.
- W2005169469 cites W2334337188 @default.
- W2005169469 cites W2343078807 @default.
- W2005169469 cites W4230887170 @default.
- W2005169469 cites W4232066112 @default.
- W2005169469 cites W4235021382 @default.
- W2005169469 cites W4236479125 @default.
- W2005169469 cites W4237969614 @default.
- W2005169469 cites W4240172047 @default.
- W2005169469 cites W4242190836 @default.
- W2005169469 cites W4254367332 @default.
- W2005169469 cites W4256364347 @default.
- W2005169469 doi "https://doi.org/10.1016/s0303-7207(99)00194-x" @default.
- W2005169469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10687854" @default.
- W2005169469 hasPublicationYear "2000" @default.
- W2005169469 type Work @default.
- W2005169469 sameAs 2005169469 @default.
- W2005169469 citedByCount "100" @default.
- W2005169469 countsByYear W20051694692012 @default.
- W2005169469 countsByYear W20051694692013 @default.
- W2005169469 countsByYear W20051694692014 @default.
- W2005169469 countsByYear W20051694692015 @default.
- W2005169469 countsByYear W20051694692016 @default.
- W2005169469 countsByYear W20051694692017 @default.
- W2005169469 countsByYear W20051694692018 @default.
- W2005169469 countsByYear W20051694692019 @default.
- W2005169469 countsByYear W20051694692020 @default.
- W2005169469 countsByYear W20051694692021 @default.
- W2005169469 countsByYear W20051694692023 @default.
- W2005169469 crossrefType "journal-article" @default.
- W2005169469 hasAuthorship W2005169469A5000424272 @default.
- W2005169469 hasAuthorship W2005169469A5009389483 @default.
- W2005169469 hasAuthorship W2005169469A5023295361 @default.
- W2005169469 hasAuthorship W2005169469A5086295953 @default.
- W2005169469 hasConcept C126322002 @default.
- W2005169469 hasConcept C134018914 @default.
- W2005169469 hasConcept C171089720 @default.
- W2005169469 hasConcept C17991360 @default.
- W2005169469 hasConcept C185592680 @default.
- W2005169469 hasConcept C2776175234 @default.
- W2005169469 hasConcept C2780613262 @default.
- W2005169469 hasConcept C511355011 @default.
- W2005169469 hasConcept C71924100 @default.
- W2005169469 hasConcept C86803240 @default.
- W2005169469 hasConceptScore W2005169469C126322002 @default.
- W2005169469 hasConceptScore W2005169469C134018914 @default.
- W2005169469 hasConceptScore W2005169469C171089720 @default.
- W2005169469 hasConceptScore W2005169469C17991360 @default.
- W2005169469 hasConceptScore W2005169469C185592680 @default.
- W2005169469 hasConceptScore W2005169469C2776175234 @default.
- W2005169469 hasConceptScore W2005169469C2780613262 @default.
- W2005169469 hasConceptScore W2005169469C511355011 @default.
- W2005169469 hasConceptScore W2005169469C71924100 @default.
- W2005169469 hasConceptScore W2005169469C86803240 @default.
- W2005169469 hasIssue "1-2" @default.
- W2005169469 hasLocation W20051694691 @default.
- W2005169469 hasLocation W20051694692 @default.
- W2005169469 hasOpenAccess W2005169469 @default.
- W2005169469 hasPrimaryLocation W20051694691 @default.
- W2005169469 hasRelatedWork W2025688934 @default.
- W2005169469 hasRelatedWork W2025731911 @default.
- W2005169469 hasRelatedWork W2077675220 @default.