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- W2005169903 endingPage "430" @default.
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- W2005169903 abstract "Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen a revitalized and uninterrupted interest. Acetaldehyde, per se, and as a product of ethanol metabolism, is responsible for many pharmacological effects which are not clearly distinguishable from those of its parent compound, ethanol. Consequently, the most recent advances in acetaldehyde's psychopharmacology have been inspired by the experimental approach to test the hypothesis that some of the effects of ethanol are mediated by acetaldehyde and, in this regard, the characterization of metabolic pathways for ethanol and the localization within discrete brain regions of these effects have revitalized the interest on the role of acetaldehyde in ethanol's central effects. Here we present and discuss a wealth of experimental evidence that converges to suggest that acetaldehyde is an intrinsically active compound, is metabolically generated in the brain and, finally, mediates many of the psychopharmacological properties of ethanol." @default.
- W2005169903 created "2016-06-24" @default.
- W2005169903 creator A5010524076 @default.
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- W2005169903 creator A5049904983 @default.
- W2005169903 creator A5059365702 @default.
- W2005169903 creator A5084372154 @default.
- W2005169903 date "2012-01-01" @default.
- W2005169903 modified "2023-10-18" @default.
- W2005169903 title "Piecing together the puzzle of acetaldehyde as a neuroactive agent" @default.
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