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- W2005173406 abstract "Abstract The metabolites of 4‐bromo‐2,5‐dimethoxyphenethylamine (2 C ‐ B ), a psychoactive drug with hallucinogenic activity, were investigated in a urine sample from a user of 2 C ‐ B . The urine sample was deconjugated enzymatically and the metabolites were recovered by liquid–liquid extraction. The extract was analyzed by gas chromatography/mass spectrometry after derivatization, and the results were used to identify and quantitate the metabolites. 4‐Bromo‐2,5‐dimethoxyphenylacetic acid was the most abundant metabolite of 2 C ‐ B in human urine and accounted for 73% of the total amount of detected metabolites, followed by 4‐bromo‐2‐hydroxy‐5‐methoxyphenylacetic acid (13%) and 4‐bromo‐2,5‐dimethoxyphenylethyl alcohol (4.5%). According to the literature, the main metabolites of 2 C ‐ B in rat urine are N ‐(4‐bromo‐2‐methoxy‐5‐hydroxyphenylethyl)acetamide and N ‐(4‐bromo‐2‐hydroxy‐5‐methoxyphenylethyl)acetamide. However, these metabolites accounted for only a small proportion of the total amount of detected metabolites in human urine, which indicates that there are significant species‐specific differences in the metabolism of 2 C ‐ B . 4‐Bromo‐2,5‐dimethoxyphenylacetic acid, which was the most abundant metabolite in human urine, is thought to be generated by deamination of 2 C ‐ B by monoamine oxidase (MAO) followed by oxidation by aldehyde dehydrogenase. Our results suggest that MAO plays a crucial role in the metabolism of 2 C ‐ B in humans." @default.
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- W2005173406 date "2012-10-15" @default.
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- W2005173406 title "Analysis of 4-Bromo-2,5-DimethoxyphenethylamineAbuser's Urine: Identification and Quantitation of Urinary Metabolites" @default.
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- W2005173406 doi "https://doi.org/10.1111/j.1556-4029.2012.02289.x" @default.
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