Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005175251> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2005175251 endingPage "358" @default.
- W2005175251 startingPage "353" @default.
- W2005175251 abstract "SLC11A1 (solute carrier family 11 member A1) protein is located on the phagolysosome membrane of macrophages and participates in bacterial killing. Here we have extended our previous work on the investigation of the potential association of polymorphisms of the 3'untranslated region (UTR) of SLC11A1 gene with test-positivity of goats to Mycobacterium avium subsp. paratuberculosis (MAP). Blood, serum and faeces were collected from 223 adult goats, from nine goat farms from Greece with a long-term record of paratuberculosis but no vaccination or tuberculin testing. The samples were subjected to sequence and structure analysis of the SLC11A1 gene and were evaluated by ELISA, culture and real time polymerase chain reaction. The 3'UTR region of the targeted gene revealed 2 microsatellites consisting of a variable number of guanine-thymine repeats named regions A and B. Statistically significant association was recorded between genotypes of region B and ELISA results, whereas the presence of B(7) allele was found to contribute to ELISA negativity. The comparison of the SLC11A1 mRNA level pre- and post-exposure to MAP shows elevated gene expression especially at the 3-h time point, in all macrophages tested regardless of their genotype. Unfortunately the latter could not be linked at a statistically significant level with any of the targeted genetic polymorphisms separately. In conclusion it can be stated that the evidence reported here provide the first indications on the association of B genotypes of the SLC11A1 gene and the detection of MAP-specific antibody by ELISA in goats." @default.
- W2005175251 created "2016-06-24" @default.
- W2005175251 creator A5027706277 @default.
- W2005175251 creator A5037650310 @default.
- W2005175251 creator A5053826739 @default.
- W2005175251 creator A5057708377 @default.
- W2005175251 date "2010-08-01" @default.
- W2005175251 modified "2023-10-17" @default.
- W2005175251 title "Investigation of the association of the SLC11A1 gene with resistance/sensitivity of goats (Capra hircus) to paratuberculosis" @default.
- W2005175251 cites W1976994054 @default.
- W2005175251 cites W1992764470 @default.
- W2005175251 cites W1995309889 @default.
- W2005175251 cites W1999103491 @default.
- W2005175251 cites W2027657858 @default.
- W2005175251 cites W2032022850 @default.
- W2005175251 cites W2063585763 @default.
- W2005175251 cites W2099529892 @default.
- W2005175251 cites W2106267258 @default.
- W2005175251 cites W2107273332 @default.
- W2005175251 cites W2107277218 @default.
- W2005175251 cites W2116679860 @default.
- W2005175251 cites W2131090195 @default.
- W2005175251 cites W2137770196 @default.
- W2005175251 cites W2149527815 @default.
- W2005175251 cites W2157931454 @default.
- W2005175251 cites W2165842486 @default.
- W2005175251 cites W2166646900 @default.
- W2005175251 cites W2279577905 @default.
- W2005175251 cites W4255033892 @default.
- W2005175251 doi "https://doi.org/10.1016/j.vetmic.2010.01.009" @default.
- W2005175251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20188496" @default.
- W2005175251 hasPublicationYear "2010" @default.
- W2005175251 type Work @default.
- W2005175251 sameAs 2005175251 @default.
- W2005175251 citedByCount "28" @default.
- W2005175251 countsByYear W20051752512012 @default.
- W2005175251 countsByYear W20051752512013 @default.
- W2005175251 countsByYear W20051752512014 @default.
- W2005175251 countsByYear W20051752512015 @default.
- W2005175251 countsByYear W20051752512017 @default.
- W2005175251 countsByYear W20051752512018 @default.
- W2005175251 countsByYear W20051752512020 @default.
- W2005175251 countsByYear W20051752512021 @default.
- W2005175251 countsByYear W20051752512023 @default.
- W2005175251 crossrefType "journal-article" @default.
- W2005175251 hasAuthorship W2005175251A5027706277 @default.
- W2005175251 hasAuthorship W2005175251A5037650310 @default.
- W2005175251 hasAuthorship W2005175251A5053826739 @default.
- W2005175251 hasAuthorship W2005175251A5057708377 @default.
- W2005175251 hasConcept C104317684 @default.
- W2005175251 hasConcept C135763542 @default.
- W2005175251 hasConcept C180754005 @default.
- W2005175251 hasConcept C2777849792 @default.
- W2005175251 hasConcept C2780374374 @default.
- W2005175251 hasConcept C2991667299 @default.
- W2005175251 hasConcept C49105822 @default.
- W2005175251 hasConcept C523546767 @default.
- W2005175251 hasConcept C54355233 @default.
- W2005175251 hasConcept C86803240 @default.
- W2005175251 hasConcept C90856448 @default.
- W2005175251 hasConceptScore W2005175251C104317684 @default.
- W2005175251 hasConceptScore W2005175251C135763542 @default.
- W2005175251 hasConceptScore W2005175251C180754005 @default.
- W2005175251 hasConceptScore W2005175251C2777849792 @default.
- W2005175251 hasConceptScore W2005175251C2780374374 @default.
- W2005175251 hasConceptScore W2005175251C2991667299 @default.
- W2005175251 hasConceptScore W2005175251C49105822 @default.
- W2005175251 hasConceptScore W2005175251C523546767 @default.
- W2005175251 hasConceptScore W2005175251C54355233 @default.
- W2005175251 hasConceptScore W2005175251C86803240 @default.
- W2005175251 hasConceptScore W2005175251C90856448 @default.
- W2005175251 hasIssue "3-4" @default.
- W2005175251 hasLocation W20051752511 @default.
- W2005175251 hasLocation W20051752512 @default.
- W2005175251 hasOpenAccess W2005175251 @default.
- W2005175251 hasPrimaryLocation W20051752511 @default.
- W2005175251 hasRelatedWork W1016159219 @default.
- W2005175251 hasRelatedWork W2008843816 @default.
- W2005175251 hasRelatedWork W2027619390 @default.
- W2005175251 hasRelatedWork W2057739827 @default.
- W2005175251 hasRelatedWork W2070922469 @default.
- W2005175251 hasRelatedWork W2223919059 @default.
- W2005175251 hasRelatedWork W2393464409 @default.
- W2005175251 hasRelatedWork W2409745059 @default.
- W2005175251 hasRelatedWork W2883538728 @default.
- W2005175251 hasRelatedWork W3206047998 @default.
- W2005175251 hasVolume "144" @default.
- W2005175251 isParatext "false" @default.
- W2005175251 isRetracted "false" @default.
- W2005175251 magId "2005175251" @default.
- W2005175251 workType "article" @default.