Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005178908> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2005178908 endingPage "1559" @default.
- W2005178908 startingPage "1555" @default.
- W2005178908 abstract "Blastogenesis of autoreactive T lymphocytes in the autologous mixed lymphocyte reaction has been shown to be decreased in patients with primary biliary cirrhosis, but the mechanisms underlying this abnormality are not known. To investigate further the abnormal autologous mixed lymphocyte reaction in primary biliary cirrhosis, we measured the activation of autoreactive helper/inducer and suppressor/cytotoxic T lymphocytes concurrently with blastogenesis in 35 patients with primary biliary cirrhosis and 18 healthy controls. Blastogenesis was diminished in autologous mixed lymphocyte reaction cultures from primary biliary cirrhosis patients compared to the control subjects (25,273 +/- 20,259 dpm vs. 36,004 +/- 14,951 dpm, p less than 0.02), but cultures from patients with primary biliary cirrhosis contained significantly increased percentages of activated helper/inducer and suppressor/cytotoxic T lymphocytes: 20.6 +/- 7.9 vs. 15.5 +/- 5.3%, p less than 0.008, and 9.8 +/- 7.8 vs. 5.4 +/- 3.0%, p less than 0.02, respectively. These findings were not related to the histologic stage of liver disease or to the serum bilirubin concentration and were not associated with abnormalities of lymphocyte subsets in fresh peripheral blood specimens. We conclude that the percentage of autoreactive T lymphocytes in autologous mixed lymphocyte reaction cultures from peripheral blood is increased in patients with primary biliary cirrhosis and diminished blastogenesis in autologous mixed lymphocyte reaction cultures is not due to the loss of autoreactive T lymphocytes from peripheral blood. Diminished blastogenesis reflects a diminished proliferative response of activated, autoreactive T lymphocytes in primary biliary cirrhosis. Possible mechanisms that may account for the paradoxical findings of decreased blastogenesis and increased activation of autoreactive T lymphocytes in primary biliary cirrhosis are discussed.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2005178908 created "2016-06-24" @default.
- W2005178908 creator A5031764164 @default.
- W2005178908 creator A5064277722 @default.
- W2005178908 creator A5071407810 @default.
- W2005178908 creator A5072153699 @default.
- W2005178908 date "1988-11-01" @default.
- W2005178908 modified "2023-09-24" @default.
- W2005178908 title "The autologous mixed lymphocyte reaction in primary biliary cirrhosis: Analysis of activation and blastogenesis of autoreactive T lymphocytes" @default.
- W2005178908 cites W1982082262 @default.
- W2005178908 cites W1984191272 @default.
- W2005178908 cites W1985226601 @default.
- W2005178908 cites W2002902455 @default.
- W2005178908 cites W2009133364 @default.
- W2005178908 cites W2011059903 @default.
- W2005178908 cites W2022749462 @default.
- W2005178908 cites W2028798921 @default.
- W2005178908 cites W2040375465 @default.
- W2005178908 cites W2047318335 @default.
- W2005178908 cites W2048143772 @default.
- W2005178908 cites W2099142178 @default.
- W2005178908 cites W2121159152 @default.
- W2005178908 cites W2339379332 @default.
- W2005178908 doi "https://doi.org/10.1002/hep.1840080614" @default.
- W2005178908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3263933" @default.
- W2005178908 hasPublicationYear "1988" @default.
- W2005178908 type Work @default.
- W2005178908 sameAs 2005178908 @default.
- W2005178908 citedByCount "15" @default.
- W2005178908 crossrefType "journal-article" @default.
- W2005178908 hasAuthorship W2005178908A5031764164 @default.
- W2005178908 hasAuthorship W2005178908A5064277722 @default.
- W2005178908 hasAuthorship W2005178908A5071407810 @default.
- W2005178908 hasAuthorship W2005178908A5072153699 @default.
- W2005178908 hasBestOaLocation W20051789081 @default.
- W2005178908 hasConcept C126322002 @default.
- W2005178908 hasConcept C154317977 @default.
- W2005178908 hasConcept C159654299 @default.
- W2005178908 hasConcept C202751555 @default.
- W2005178908 hasConcept C203014093 @default.
- W2005178908 hasConcept C2776090121 @default.
- W2005178908 hasConcept C2777214474 @default.
- W2005178908 hasConcept C2777761686 @default.
- W2005178908 hasConcept C2778740727 @default.
- W2005178908 hasConcept C2779075594 @default.
- W2005178908 hasConcept C2780366471 @default.
- W2005178908 hasConcept C2992881475 @default.
- W2005178908 hasConcept C2994419564 @default.
- W2005178908 hasConcept C55493867 @default.
- W2005178908 hasConcept C71924100 @default.
- W2005178908 hasConcept C86803240 @default.
- W2005178908 hasConcept C8891405 @default.
- W2005178908 hasConceptScore W2005178908C126322002 @default.
- W2005178908 hasConceptScore W2005178908C154317977 @default.
- W2005178908 hasConceptScore W2005178908C159654299 @default.
- W2005178908 hasConceptScore W2005178908C202751555 @default.
- W2005178908 hasConceptScore W2005178908C203014093 @default.
- W2005178908 hasConceptScore W2005178908C2776090121 @default.
- W2005178908 hasConceptScore W2005178908C2777214474 @default.
- W2005178908 hasConceptScore W2005178908C2777761686 @default.
- W2005178908 hasConceptScore W2005178908C2778740727 @default.
- W2005178908 hasConceptScore W2005178908C2779075594 @default.
- W2005178908 hasConceptScore W2005178908C2780366471 @default.
- W2005178908 hasConceptScore W2005178908C2992881475 @default.
- W2005178908 hasConceptScore W2005178908C2994419564 @default.
- W2005178908 hasConceptScore W2005178908C55493867 @default.
- W2005178908 hasConceptScore W2005178908C71924100 @default.
- W2005178908 hasConceptScore W2005178908C86803240 @default.
- W2005178908 hasConceptScore W2005178908C8891405 @default.
- W2005178908 hasIssue "6" @default.
- W2005178908 hasLocation W20051789081 @default.
- W2005178908 hasLocation W20051789082 @default.
- W2005178908 hasOpenAccess W2005178908 @default.
- W2005178908 hasPrimaryLocation W20051789081 @default.
- W2005178908 hasRelatedWork W146591177 @default.
- W2005178908 hasRelatedWork W1506984959 @default.
- W2005178908 hasRelatedWork W1794516688 @default.
- W2005178908 hasRelatedWork W2003641733 @default.
- W2005178908 hasRelatedWork W2005178908 @default.
- W2005178908 hasRelatedWork W2018979778 @default.
- W2005178908 hasRelatedWork W2025135494 @default.
- W2005178908 hasRelatedWork W2027944036 @default.
- W2005178908 hasRelatedWork W2056385328 @default.
- W2005178908 hasRelatedWork W91868852 @default.
- W2005178908 hasVolume "8" @default.
- W2005178908 isParatext "false" @default.
- W2005178908 isRetracted "false" @default.
- W2005178908 magId "2005178908" @default.
- W2005178908 workType "article" @default.