FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005179084> ?p ?o ?g. }

• W2005179084 endingPage "1114" @default.
• W2005179084 startingPage "1103" @default.
• W2005179084 abstract "Modulation of dendrodendritic synapses by the noradrenergic system in the accessory olfactory bulb (AOB) plays a key role in the formation of memory in olfactory-mediated behaviors. We have recently shown that noradrenaline (NA) inhibits mitral cells by increasing γ-aminobutyric acid inhibitory input onto mitral cells in the AOB, suggesting an excitatory action of NA on granule cells (GCs). Here, we show that NA (10 μM) elicits a long-lasting depolarization of GCs. This effect is mediated by activation of α 1 -adrenergic receptors as the depolarization is mimicked by phenylephrine (PE, 30 μM) and completely blocked by the α 1 -adrenergic receptor antagonist prazosin (300 nM). In addition to this depolarization, application of NA induced the appearance of a slow afterdepolarization (sADP) following a stimulus-elicited train of action potentials. Similarly, the group I metabotropic glutamate receptor (mGluR1) agonist DHPG (10–30 μM) also produced a depolarization of GCs and the appearance of a stimulus-induced sADP. The ionic and voltage dependence and sensitivity to blockers of the sADP suggest that it is mediated by the nonselective cationic conductance I CAN . Thus the excitatory action resulting from the activation of these receptors could be mediated by a common transduction target. Surprisingly, the excitatory effect of PE on GCs was completely blocked by the mGluR1 antagonist LY367385 (100 μM). Conversely, the effect of DHPG was not antagonized by the α 1 -adrenergic receptor antagonist prazosin (300 nM). These results suggest that most of the noradrenergic effect on GCs in the AOB is mediated by potentiation of a basal activity of mGluR1s." @default.
• W2005179084 created "2016-06-24" @default.
• W2005179084 creator A5007483638 @default.
• W2005179084 creator A5027985861 @default.
• W2005179084 creator A5063035669 @default.
• W2005179084 date "2009-08-01" @default.
• W2005179084 modified "2023-10-09" @default.
• W2005179084 title "Excitatory Actions of Noradrenaline and Metabotropic Glutamate Receptor Activation in Granule Cells of the Accessory Olfactory Bulb" @default.
• W2005179084 cites W1815738849 @default.
• W2005179084 cites W1963590565 @default.
• W2005179084 cites W1965302582 @default.
• W2005179084 cites W1969818869 @default.
• W2005179084 cites W1977652367 @default.
• W2005179084 cites W1979112681 @default.
• W2005179084 cites W1983022541 @default.
• W2005179084 cites W1983074292 @default.
• W2005179084 cites W1983489113 @default.
• W2005179084 cites W1985407755 @default.
• W2005179084 cites W1985925705 @default.
• W2005179084 cites W1987673795 @default.
• W2005179084 cites W1990472301 @default.
• W2005179084 cites W1993481663 @default.
• W2005179084 cites W1994153884 @default.
• W2005179084 cites W1997134830 @default.
• W2005179084 cites W1997941412 @default.
• W2005179084 cites W1997941486 @default.
• W2005179084 cites W2000756368 @default.
• W2005179084 cites W2001383967 @default.
• W2005179084 cites W2016329811 @default.
• W2005179084 cites W2026430201 @default.
• W2005179084 cites W2026971496 @default.
• W2005179084 cites W2029148243 @default.
• W2005179084 cites W2032954084 @default.
• W2005179084 cites W2034446506 @default.
• W2005179084 cites W2039548603 @default.
• W2005179084 cites W2041492540 @default.
• W2005179084 cites W2046144675 @default.
• W2005179084 cites W2057331892 @default.
• W2005179084 cites W2058134404 @default.
• W2005179084 cites W2061949345 @default.
• W2005179084 cites W2066793044 @default.
• W2005179084 cites W2067397814 @default.
• W2005179084 cites W2068083086 @default.
• W2005179084 cites W2069955367 @default.
• W2005179084 cites W2077838565 @default.
• W2005179084 cites W2079028909 @default.
• W2005179084 cites W2083571423 @default.
• W2005179084 cites W2087093988 @default.
• W2005179084 cites W2092348831 @default.
• W2005179084 cites W2092593471 @default.
• W2005179084 cites W2092793802 @default.
• W2005179084 cites W2094431984 @default.
• W2005179084 cites W2102721930 @default.
• W2005179084 cites W2106042714 @default.
• W2005179084 cites W2125619691 @default.
• W2005179084 cites W2143464852 @default.
• W2005179084 cites W2162829122 @default.
• W2005179084 cites W2166718217 @default.
• W2005179084 cites W2268274914 @default.
• W2005179084 cites W2399763991 @default.
• W2005179084 cites W2471637005 @default.
• W2005179084 cites W2484042308 @default.
• W2005179084 doi "https://doi.org/10.1152/jn.91093.2008" @default.
• W2005179084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2724365" @default.
• W2005179084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19474170" @default.
• W2005179084 hasPublicationYear "2009" @default.
• W2005179084 type Work @default.
• W2005179084 sameAs 2005179084 @default.
• W2005179084 citedByCount "38" @default.
• W2005179084 countsByYear W20051790842012 @default.
• W2005179084 countsByYear W20051790842013 @default.
• W2005179084 countsByYear W20051790842014 @default.
• W2005179084 countsByYear W20051790842015 @default.
• W2005179084 countsByYear W20051790842016 @default.
• W2005179084 countsByYear W20051790842017 @default.
• W2005179084 countsByYear W20051790842018 @default.
• W2005179084 countsByYear W20051790842019 @default.
• W2005179084 countsByYear W20051790842020 @default.
• W2005179084 countsByYear W20051790842022 @default.
• W2005179084 countsByYear W20051790842023 @default.
• W2005179084 crossrefType "journal-article" @default.
• W2005179084 hasAuthorship W2005179084A5007483638 @default.
• W2005179084 hasAuthorship W2005179084A5027985861 @default.
• W2005179084 hasAuthorship W2005179084A5063035669 @default.
• W2005179084 hasBestOaLocation W20051790842 @default.
• W2005179084 hasConcept C112592302 @default.
• W2005179084 hasConcept C12554922 @default.
• W2005179084 hasConcept C126322002 @default.
• W2005179084 hasConcept C169760540 @default.
• W2005179084 hasConcept C170493617 @default.
• W2005179084 hasConcept C17077164 @default.
• W2005179084 hasConcept C185592680 @default.
• W2005179084 hasConcept C26702167 @default.
• W2005179084 hasConcept C2776885963 @default.
• W2005179084 hasConcept C2780496858 @default.
• W2005179084 hasConcept C2780648677 @default.
• W2005179084 hasConcept C4141045 @default.
• W2005179084 hasConcept C49051014 @default.

• next