FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005180190> ?p ?o ?g. }

• W2005180190 endingPage "e1004674" @default.
• W2005180190 startingPage "e1004674" @default.
• W2005180190 abstract "Plant disease resistance is often mediated by nucleotide binding-leucine rich repeat (NLR) proteins which remain auto-inhibited until recognition of specific pathogen-derived molecules causes their activation, triggering a rapid, localized cell death called a hypersensitive response (HR). Three domains are recognized in one of the major classes of NLR proteins: a coiled-coil (CC), a nucleotide binding (NB-ARC) and a leucine rich repeat (LRR) domains. The maize NLR gene Rp1-D21 derives from an intergenic recombination event between two NLR genes, Rp1-D and Rp1-dp2 and confers an autoactive HR. We report systematic structural and functional analyses of Rp1 proteins in maize and N. benthamiana to characterize the molecular mechanism of NLR activation/auto-inhibition. We derive a model comprising the following three main features: Rp1 proteins appear to self-associate to become competent for activity. The CC domain is signaling-competent and is sufficient to induce HR. This can be suppressed by the NB-ARC domain through direct interaction. In autoactive proteins, the interaction of the LRR domain with the NB-ARC domain causes de-repression and thus disrupts the inhibition of HR. Further, we identify specific amino acids and combinations thereof that are important for the auto-inhibition/activity of Rp1 proteins. We also provide evidence for the function of MHD2, a previously uncharacterized, though widely conserved NLR motif. This work reports several novel insights into the precise structural requirement for NLR function and informs efforts towards utilizing these proteins for engineering disease resistance." @default.
• W2005180190 created "2016-06-24" @default.
• W2005180190 creator A5030771368 @default.
• W2005180190 creator A5039313376 @default.
• W2005180190 creator A5063070577 @default.
• W2005180190 creator A5068223075 @default.
• W2005180190 creator A5076673606 @default.
• W2005180190 creator A5082498150 @default.
• W2005180190 date "2015-02-26" @default.
• W2005180190 modified "2023-10-13" @default.
• W2005180190 title "Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity" @default.
• W2005180190 cites W1518701384 @default.
• W2005180190 cites W1562117258 @default.
• W2005180190 cites W1962709384 @default.
• W2005180190 cites W1966773931 @default.
• W2005180190 cites W1973328229 @default.
• W2005180190 cites W1974855449 @default.
• W2005180190 cites W1977557566 @default.
• W2005180190 cites W1981932072 @default.
• W2005180190 cites W1984675152 @default.
• W2005180190 cites W1989581558 @default.
• W2005180190 cites W1991990550 @default.
• W2005180190 cites W1996573117 @default.
• W2005180190 cites W1998053175 @default.
• W2005180190 cites W2006647800 @default.
• W2005180190 cites W2018806611 @default.
• W2005180190 cites W2030310185 @default.
• W2005180190 cites W2039814762 @default.
• W2005180190 cites W2040424931 @default.
• W2005180190 cites W2040978761 @default.
• W2005180190 cites W2049372309 @default.
• W2005180190 cites W2049579557 @default.
• W2005180190 cites W2049886969 @default.
• W2005180190 cites W2050280736 @default.
• W2005180190 cites W2052948816 @default.
• W2005180190 cites W2060259273 @default.
• W2005180190 cites W2062997550 @default.
• W2005180190 cites W2065727408 @default.
• W2005180190 cites W2072259950 @default.
• W2005180190 cites W2074888340 @default.
• W2005180190 cites W2076773821 @default.
• W2005180190 cites W2082026887 @default.
• W2005180190 cites W2083300694 @default.
• W2005180190 cites W2084368396 @default.
• W2005180190 cites W2086495398 @default.
• W2005180190 cites W2087128996 @default.
• W2005180190 cites W2087675271 @default.
• W2005180190 cites W2090723161 @default.
• W2005180190 cites W2090881705 @default.
• W2005180190 cites W2100323315 @default.
• W2005180190 cites W2104020627 @default.
• W2005180190 cites W2106524515 @default.
• W2005180190 cites W2108419807 @default.
• W2005180190 cites W2108733083 @default.
• W2005180190 cites W2113076963 @default.
• W2005180190 cites W2113125872 @default.
• W2005180190 cites W2117534309 @default.
• W2005180190 cites W2118111553 @default.
• W2005180190 cites W2119735766 @default.
• W2005180190 cites W2121429996 @default.
• W2005180190 cites W2122800135 @default.
• W2005180190 cites W2123679376 @default.
• W2005180190 cites W2123762144 @default.
• W2005180190 cites W2126666450 @default.
• W2005180190 cites W2126841200 @default.
• W2005180190 cites W2130330131 @default.
• W2005180190 cites W2132198143 @default.
• W2005180190 cites W2134480400 @default.
• W2005180190 cites W2136931477 @default.
• W2005180190 cites W2138261448 @default.
• W2005180190 cites W2138405903 @default.
• W2005180190 cites W2138472234 @default.
• W2005180190 cites W2139134943 @default.
• W2005180190 cites W2140302681 @default.
• W2005180190 cites W2145611203 @default.
• W2005180190 cites W2153558019 @default.
• W2005180190 cites W2154540205 @default.
• W2005180190 cites W2155452888 @default.
• W2005180190 cites W2160155425 @default.
• W2005180190 cites W2162800927 @default.
• W2005180190 cites W2171192872 @default.
• W2005180190 doi "https://doi.org/10.1371/journal.ppat.1004674" @default.
• W2005180190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4393323" @default.
• W2005180190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25859856" @default.
• W2005180190 hasPublicationYear "2015" @default.
• W2005180190 type Work @default.
• W2005180190 sameAs 2005180190 @default.
• W2005180190 citedByCount "105" @default.
• W2005180190 countsByYear W20051801902015 @default.
• W2005180190 countsByYear W20051801902016 @default.
• W2005180190 countsByYear W20051801902017 @default.
• W2005180190 countsByYear W20051801902018 @default.
• W2005180190 countsByYear W20051801902019 @default.
• W2005180190 countsByYear W20051801902020 @default.
• W2005180190 countsByYear W20051801902021 @default.
• W2005180190 countsByYear W20051801902022 @default.
• W2005180190 countsByYear W20051801902023 @default.
• W2005180190 crossrefType "journal-article" @default.

• next