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• W2005185610 abstract "Abstract Ubiquitin-specific protease USP4 is emerging as an important regulator of cellular pathways, including the TGF-β response, NF-κB signalling and splicing, with possible roles in cancer. Here we show that USP4 has its catalytic triad arranged in a productive conformation. Nevertheless, it requires its N-terminal DUSP–Ubl domain to achieve full catalytic turnover. Pre-steady-state kinetics measurements reveal that USP4 catalytic domain activity is strongly inhibited by slow dissociation of ubiquitin after substrate hydrolysis. The DUSP–Ubl domain is able to enhance ubiquitin dissociation, hence promoting efficient turnover. In a mechanism that requires all USP4 domains, binding of the DUSP–Ubl domain promotes a change of a switching loop near the active site. This ‘allosteric regulation of product discharge’ provides a novel way of regulating deubiquitinating enzymes that may have relevance for other enzyme classes." @default.
• W2005185610 created "2016-06-24" @default.
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• W2005185610 date "2014-11-18" @default.
• W2005185610 modified "2023-10-06" @default.
• W2005185610 title "The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange" @default.
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• W2005185610 doi "https://doi.org/10.1038/ncomms6399" @default.
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