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• W2005186890 startingPage "4139" @default.
• W2005186890 abstract "A vitamin B(6) degradative pathway has recently been identified and characterized in Mesorhizobium loti MAFF303099. One of the enzymes on this pathway, 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO), is a flavin-dependent enzyme and catalyzes the oxidative ring-opening of 2-methyl-3-hydroxypyridine-5-carboxylic acid to form E-2-(acetamino-methylene)succinate. The gene for this enzyme has been cloned, and the corresponding protein has been overexpressed in Escherichia coli and purified. The crystal structure of MHPCO has been solved to 2.1 A using SAD phasing with and without the substrate MHPC bound. These crystal structures provide insight into the reaction mechanism and suggest roles for active site residues in the catalysis of a novel oxidative ring-opening reaction." @default.
• W2005186890 created "2016-06-24" @default.
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• W2005186890 date "2009-04-01" @default.
• W2005186890 modified "2023-10-13" @default.
• W2005186890 title "Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from <i>Mesorhizobium loti</i> MAFF303099 and Its Mechanistic Implications" @default.
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• W2005186890 doi "https://doi.org/10.1021/bi900149f" @default.
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