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• W2005188909 abstract "The present study was aimed at investigating whether two-kidney, one clip (2K1C) hypertension is associated with an enhanced central adrenergic activity. Rats were made 2K1C hypertensive, and the expression of Fos-like immunoreactivity (FLI) and phenylethanalamine N-methyltransferase (PNMT)-immunoreactivity was determined in the brain areas related to the cardiovascular regulation. In 2K1C hypertension, the basal Fos-immunoreactivity was significantly increased in rostral ventrolateral medulla (RVLM), paraventricular nucleus (PVN), and supraoptic nucleus (SON). PNMT-immunoreactivities were noted in RVLM, but not in PVN or SON. Intracerebroventricular administration of angiotensin II (AII) markedly increased Fos-immunoreactivities, the degree of which was greater in hypertension. Furthermore, AII increased the ratio of PNMT-positive/Fos-positive neurons in RVLM in hypertension. It is suggested that the responsiveness to AII of the central adrenergic system is enhanced in 2K1C hypertension." @default.
• W2005188909 created "2016-06-24" @default.
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• W2005188909 date "2004-10-01" @default.
• W2005188909 modified "2023-10-16" @default.
• W2005188909 title "Enhanced activity of central adrenergic neurons in two-kidney, one clip hypertension in Sprague–Dawley rats" @default.
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• W2005188909 doi "https://doi.org/10.1016/j.neulet.2004.07.029" @default.
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