FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005196005> ?p ?o ?g. }

• W2005196005 endingPage "e98835" @default.
• W2005196005 startingPage "e98835" @default.
• W2005196005 abstract "Chronic adipose tissue inflammation is a hallmark of obesity-induced insulin resistance and anti-inflammatory agents can benefit patients with obesity-associated syndromes. Currently available type I interferons for therapeutic immunomodulation are accompanied by high cytotoxicity and therefore in this study we have examined anti-inflammatory effects of interferon tau (IFNT), a member of the type I interferon family with low cellular toxicity even at high doses. Using a diet-induced obesity mouse model, we observed enhanced insulin sensitivity in obese mice administered IFNT compared to control mice, which was accompanied by a significant decrease in secretion of proinflammatory cytokines and elevated anti-inflammatory macrophages (M2) in adipose tissue. Further investigations revealed that IFNT is a potent regulator of macrophage activation that favors anti-inflammatory responses as evidenced by activation of associated surface antigens, production of anti-inflammatory cytokines, and activation of selective cell signaling pathways. Thus, our study demonstrates, for the first time, that IFNT can significantly mitigate obesity-associated systemic insulin resistance and tissue inflammation by controlling macrophage polarization, and thus IFNT can be a novel bio-therapeutic agent for treating obesity-associated syndromes and type 2 diabetes." @default.
• W2005196005 created "2016-06-24" @default.
• W2005196005 creator A5012486717 @default.
• W2005196005 creator A5021286537 @default.
• W2005196005 creator A5033698833 @default.
• W2005196005 creator A5036575223 @default.
• W2005196005 creator A5042251994 @default.
• W2005196005 creator A5055321638 @default.
• W2005196005 creator A5083904849 @default.
• W2005196005 date "2014-06-06" @default.
• W2005196005 modified "2023-10-01" @default.
• W2005196005 title "Interferon Tau Alleviates Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Macrophage Polarization" @default.
• W2005196005 cites W1493167376 @default.
• W2005196005 cites W1518576897 @default.
• W2005196005 cites W1567143942 @default.
• W2005196005 cites W1676529079 @default.
• W2005196005 cites W1964271390 @default.
• W2005196005 cites W2012713541 @default.
• W2005196005 cites W2020173029 @default.
• W2005196005 cites W2048227276 @default.
• W2005196005 cites W2062018306 @default.
• W2005196005 cites W2073882423 @default.
• W2005196005 cites W2085243036 @default.
• W2005196005 cites W2090578530 @default.
• W2005196005 cites W2099536385 @default.
• W2005196005 cites W2104680689 @default.
• W2005196005 cites W2110872329 @default.
• W2005196005 cites W2116814173 @default.
• W2005196005 cites W2119298240 @default.
• W2005196005 cites W2125029777 @default.
• W2005196005 cites W2130495917 @default.
• W2005196005 cites W2130874539 @default.
• W2005196005 cites W2135507245 @default.
• W2005196005 cites W2144722946 @default.
• W2005196005 cites W2145697808 @default.
• W2005196005 cites W2146957741 @default.
• W2005196005 cites W2165202791 @default.
• W2005196005 cites W2165334726 @default.
• W2005196005 cites W2167485774 @default.
• W2005196005 cites W2335409600 @default.
• W2005196005 cites W4238497443 @default.
• W2005196005 cites W4249727000 @default.
• W2005196005 doi "https://doi.org/10.1371/journal.pone.0098835" @default.
• W2005196005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4048269" @default.
• W2005196005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24905566" @default.
• W2005196005 hasPublicationYear "2014" @default.
• W2005196005 type Work @default.
• W2005196005 sameAs 2005196005 @default.
• W2005196005 citedByCount "25" @default.
• W2005196005 countsByYear W20051960052015 @default.
• W2005196005 countsByYear W20051960052016 @default.
• W2005196005 countsByYear W20051960052017 @default.
• W2005196005 countsByYear W20051960052018 @default.
• W2005196005 countsByYear W20051960052019 @default.
• W2005196005 countsByYear W20051960052020 @default.
• W2005196005 countsByYear W20051960052021 @default.
• W2005196005 countsByYear W20051960052022 @default.
• W2005196005 countsByYear W20051960052023 @default.
• W2005196005 crossrefType "journal-article" @default.
• W2005196005 hasAuthorship W2005196005A5012486717 @default.
• W2005196005 hasAuthorship W2005196005A5021286537 @default.
• W2005196005 hasAuthorship W2005196005A5033698833 @default.
• W2005196005 hasAuthorship W2005196005A5036575223 @default.
• W2005196005 hasAuthorship W2005196005A5042251994 @default.
• W2005196005 hasAuthorship W2005196005A5055321638 @default.
• W2005196005 hasAuthorship W2005196005A5083904849 @default.
• W2005196005 hasBestOaLocation W20051960051 @default.
• W2005196005 hasConcept C126322002 @default.
• W2005196005 hasConcept C134018914 @default.
• W2005196005 hasConcept C164027704 @default.
• W2005196005 hasConcept C171089720 @default.
• W2005196005 hasConcept C17675752 @default.
• W2005196005 hasConcept C202751555 @default.
• W2005196005 hasConcept C203014093 @default.
• W2005196005 hasConcept C2776682551 @default.
• W2005196005 hasConcept C2776914184 @default.
• W2005196005 hasConcept C2777180221 @default.
• W2005196005 hasConcept C2777391703 @default.
• W2005196005 hasConcept C2779244956 @default.
• W2005196005 hasConcept C2779306644 @default.
• W2005196005 hasConcept C55493867 @default.
• W2005196005 hasConcept C555293320 @default.
• W2005196005 hasConcept C71924100 @default.
• W2005196005 hasConcept C86803240 @default.
• W2005196005 hasConceptScore W2005196005C126322002 @default.
• W2005196005 hasConceptScore W2005196005C134018914 @default.
• W2005196005 hasConceptScore W2005196005C164027704 @default.
• W2005196005 hasConceptScore W2005196005C171089720 @default.
• W2005196005 hasConceptScore W2005196005C17675752 @default.
• W2005196005 hasConceptScore W2005196005C202751555 @default.
• W2005196005 hasConceptScore W2005196005C203014093 @default.
• W2005196005 hasConceptScore W2005196005C2776682551 @default.
• W2005196005 hasConceptScore W2005196005C2776914184 @default.
• W2005196005 hasConceptScore W2005196005C2777180221 @default.
• W2005196005 hasConceptScore W2005196005C2777391703 @default.
• W2005196005 hasConceptScore W2005196005C2779244956 @default.
• W2005196005 hasConceptScore W2005196005C2779306644 @default.
• W2005196005 hasConceptScore W2005196005C55493867 @default.

• next