FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005196318> ?p ?o ?g. }

• W2005196318 endingPage "e35500" @default.
• W2005196318 startingPage "e35500" @default.
• W2005196318 abstract "Age-related hearing impairment (ARHI) affects 25–40% of individuals over the age of 65. Despite the high prevalence of this complex trait, ARHI is still poorly understood. We hypothesized that variance in hearing ability with age is largely determined by genetic factors. We collected audiologic data on females of Northern European ancestry and compared different audiogram representations. A web-based speech-to-noise ratio (SNR) hearing test was compared with pure-tone thresholds to see if we could determine accurately hearing ability on people at home and the genetic contribution to each trait compared. Volunteers were recruited from the TwinsUK cohort. Hearing ability was determined using pure-tone audiometry and a web-based hearing test. Different audiogram presentations were compared for age-correlation and reflection of audiogram shape. Using structural equation modelling based on the classical twin model the heritability of ARHI, as measured by the different phenotypes, was estimated and shared variance between the web-based SNR test and pure-tone audiometry determined using bivariate modelling. Pure-tone audiometric data was collected on 1033 older females (age: 41–86). 1970 volunteers (males and females, age: 18–85) participated in the SNR. In the comparison between different ARHI phenotypes the difference between the first two principle components (PC1–PC2) best represented ARHI. The SNR test showed a sensitivity and specificity of 89% and 80%, respectively, in comparison with pure-tone audiogram data. Univariate heritability estimates ranged from 0.70 (95% CI: 0.63–0.76) for (PC1–PC2) to 0.56 (95% CI: 0.48–0.63) for PC2. The genetic correlation of PC1–PC2 and SNR was −0.67 showing that the 2 traits share variances attributed to additive genetic factors. Hearing ability showed considerable heritability in our sample. We have shown that the SNR test provides a useful surrogate marker of hearing. This will enable a much larger sample to be collected at a fraction of the cost, facilitating future genetic association studies." @default.
• W2005196318 created "2016-06-24" @default.
• W2005196318 creator A5002163035 @default.
• W2005196318 creator A5009232210 @default.
• W2005196318 creator A5043761421 @default.
• W2005196318 creator A5054779890 @default.
• W2005196318 date "2012-04-30" @default.
• W2005196318 modified "2023-09-26" @default.
• W2005196318 title "Hearing Ability with Age in Northern European Women: A New Web-Based Approach to Genetic Studies" @default.
• W2005196318 cites W1973378757 @default.
• W2005196318 cites W1974432160 @default.
• W2005196318 cites W1978242253 @default.
• W2005196318 cites W1980991473 @default.
• W2005196318 cites W1994773119 @default.
• W2005196318 cites W2000663528 @default.
• W2005196318 cites W2002331408 @default.
• W2005196318 cites W2015612792 @default.
• W2005196318 cites W2015795623 @default.
• W2005196318 cites W2031375292 @default.
• W2005196318 cites W2051951610 @default.
• W2005196318 cites W2070412724 @default.
• W2005196318 cites W2081422943 @default.
• W2005196318 cites W2084430101 @default.
• W2005196318 cites W2095786576 @default.
• W2005196318 cites W2100200845 @default.
• W2005196318 cites W2110252452 @default.
• W2005196318 cites W2144110983 @default.
• W2005196318 cites W2145112530 @default.
• W2005196318 cites W2153117878 @default.
• W2005196318 cites W2154566022 @default.
• W2005196318 cites W2268626592 @default.
• W2005196318 cites W2268695670 @default.
• W2005196318 cites W4230032116 @default.
• W2005196318 doi "https://doi.org/10.1371/journal.pone.0035500" @default.
• W2005196318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340381" @default.
• W2005196318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22558162" @default.
• W2005196318 hasPublicationYear "2012" @default.
• W2005196318 type Work @default.
• W2005196318 sameAs 2005196318 @default.
• W2005196318 citedByCount "23" @default.
• W2005196318 countsByYear W20051963182014 @default.
• W2005196318 countsByYear W20051963182015 @default.
• W2005196318 countsByYear W20051963182016 @default.
• W2005196318 countsByYear W20051963182017 @default.
• W2005196318 countsByYear W20051963182018 @default.
• W2005196318 countsByYear W20051963182019 @default.
• W2005196318 countsByYear W20051963182020 @default.
• W2005196318 countsByYear W20051963182021 @default.
• W2005196318 countsByYear W20051963182022 @default.
• W2005196318 countsByYear W20051963182023 @default.
• W2005196318 crossrefType "journal-article" @default.
• W2005196318 hasAuthorship W2005196318A5002163035 @default.
• W2005196318 hasAuthorship W2005196318A5009232210 @default.
• W2005196318 hasAuthorship W2005196318A5043761421 @default.
• W2005196318 hasAuthorship W2005196318A5054779890 @default.
• W2005196318 hasBestOaLocation W20051963181 @default.
• W2005196318 hasConcept C126322002 @default.
• W2005196318 hasConcept C15744967 @default.
• W2005196318 hasConcept C161890455 @default.
• W2005196318 hasConcept C17743292 @default.
• W2005196318 hasConcept C2779398211 @default.
• W2005196318 hasConcept C2780283655 @default.
• W2005196318 hasConcept C2780493683 @default.
• W2005196318 hasConcept C2780554537 @default.
• W2005196318 hasConcept C54355233 @default.
• W2005196318 hasConcept C548259974 @default.
• W2005196318 hasConcept C71924100 @default.
• W2005196318 hasConcept C86803240 @default.
• W2005196318 hasConcept C99476002 @default.
• W2005196318 hasConceptScore W2005196318C126322002 @default.
• W2005196318 hasConceptScore W2005196318C15744967 @default.
• W2005196318 hasConceptScore W2005196318C161890455 @default.
• W2005196318 hasConceptScore W2005196318C17743292 @default.
• W2005196318 hasConceptScore W2005196318C2779398211 @default.
• W2005196318 hasConceptScore W2005196318C2780283655 @default.
• W2005196318 hasConceptScore W2005196318C2780493683 @default.
• W2005196318 hasConceptScore W2005196318C2780554537 @default.
• W2005196318 hasConceptScore W2005196318C54355233 @default.
• W2005196318 hasConceptScore W2005196318C548259974 @default.
• W2005196318 hasConceptScore W2005196318C71924100 @default.
• W2005196318 hasConceptScore W2005196318C86803240 @default.
• W2005196318 hasConceptScore W2005196318C99476002 @default.
• W2005196318 hasIssue "4" @default.
• W2005196318 hasLocation W20051963181 @default.
• W2005196318 hasLocation W20051963182 @default.
• W2005196318 hasLocation W20051963183 @default.
• W2005196318 hasLocation W20051963184 @default.
• W2005196318 hasLocation W20051963185 @default.
• W2005196318 hasLocation W20051963186 @default.
• W2005196318 hasOpenAccess W2005196318 @default.
• W2005196318 hasPrimaryLocation W20051963181 @default.
• W2005196318 hasRelatedWork W1883906525 @default.
• W2005196318 hasRelatedWork W1965774976 @default.
• W2005196318 hasRelatedWork W2037394773 @default.
• W2005196318 hasRelatedWork W2112463353 @default.
• W2005196318 hasRelatedWork W2372525713 @default.
• W2005196318 hasRelatedWork W2914761248 @default.
• W2005196318 hasRelatedWork W2980997172 @default.

• next