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- W2005200305 abstract "Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death." @default.
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- W2005200305 date "2013-01-01" @default.
- W2005200305 modified "2023-09-23" @default.
- W2005200305 title "Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis" @default.
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- W2005200305 doi "https://doi.org/10.1016/j.bmc.2012.11.016" @default.
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