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- W2005202208 abstract "Malignant pleural mesothelioma (MPM) is a fatal neoplasm with no acceptable curative approaches. We used serial analysis of gene expression (SAGE) to compare the gene expression pattern of a surgically resected MPM to the autologous normal mesothelium. Intelectin gene overexpression (>139-fold) was found in the tumor. Online SAGE datasets revealed intelectin to be consistently present in mesothelioma(s), ovarian cancer, and colon cancer. Intelectin mRNA expression was found by RT-PCR in 4 of 5 resected MPM tumors, and Intelectin protein expression was confirmed by immunohistochemistry in 28 of 53 MPM tumors, and in 4 of 4 mesothelioma cell lines studied by Western blot. A marked induction in intelectin gene expression was observed among human primary mesothelial cells as a consequence of crocidolite asbestos exposure and simian virus 40 infection. Intelectin overexpression in mesothelioma could have potential screening, and therapeutic implications." @default.
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- W2005202208 date "2005-04-01" @default.
- W2005202208 modified "2023-10-17" @default.
- W2005202208 title "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)" @default.
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- W2005202208 doi "https://doi.org/10.1016/j.lungcan.2004.10.011" @default.
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