Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005202278> ?p ?o ?g. }
- W2005202278 endingPage "542" @default.
- W2005202278 startingPage "542" @default.
- W2005202278 abstract "• The serotonin agonist m-chlorophenylpiperazine (mCPP) was administered intravenously to 12 patients with Alzheimer's disease and ten age-matched controls. It produced distinct behavioral effects in both treatment groups; however, significantly greater responsivity to mCPP was found in patients with Alzheimer's disease than in controls in measures of psychomotor activation, restlessness, and perceptual abnormalities. Significant and similar increases in plasma prolactin and cortisol levels were found in both patients with Alzheimer's disease and controls following the administration of mCPP vs placebo. Furthermore, blood pressure and pulse changes following mCPP were not significantly different between the groups. Elderly controls, however, did show a significantly greater temperature response following mCPP than did patients with Alzheimer's disease. The overall cognitive effects of mCPP were minimal; however, mCPP produced significantly greater worsening in recent memory and knowledge memory in patients with Alzheimer's disease than in controls. These findings could not be explained by pharmacokinetic differences across populations, because plasma concentrations of mCPP were similar in patients with Alzheimer's disease and controls. The increased behavioral responsivity but unchanged neuroendocrine or other physiologic responsivity to mCPP may be related to damaged brain serotonin neurons or other neuronal systems that interact with serotonin neurons that have been found in postmortem and biopsy studies of patients with Alzheimer's disease." @default.
- W2005202278 created "2016-06-24" @default.
- W2005202278 creator A5071373873 @default.
- W2005202278 date "1989-06-01" @default.
- W2005202278 modified "2023-10-16" @default.
- W2005202278 title "Hyperresponsivity to the Serotonin Agonist m-Chlorophenylpiperazine in Alzheimer's Disease" @default.
- W2005202278 cites W1546882216 @default.
- W2005202278 cites W1979501096 @default.
- W2005202278 cites W1981443436 @default.
- W2005202278 cites W1982852718 @default.
- W2005202278 cites W1985232500 @default.
- W2005202278 cites W1993377067 @default.
- W2005202278 cites W1997825517 @default.
- W2005202278 cites W2000277154 @default.
- W2005202278 cites W2002716918 @default.
- W2005202278 cites W2010627533 @default.
- W2005202278 cites W2011429800 @default.
- W2005202278 cites W2011786910 @default.
- W2005202278 cites W2013519649 @default.
- W2005202278 cites W2015797063 @default.
- W2005202278 cites W2020844317 @default.
- W2005202278 cites W2023055592 @default.
- W2005202278 cites W2023628141 @default.
- W2005202278 cites W2027107708 @default.
- W2005202278 cites W2029338703 @default.
- W2005202278 cites W2030955576 @default.
- W2005202278 cites W2031322438 @default.
- W2005202278 cites W2034969383 @default.
- W2005202278 cites W2036286675 @default.
- W2005202278 cites W2037651109 @default.
- W2005202278 cites W2040294022 @default.
- W2005202278 cites W2041321583 @default.
- W2005202278 cites W2045736143 @default.
- W2005202278 cites W2053178767 @default.
- W2005202278 cites W2054345964 @default.
- W2005202278 cites W2056637816 @default.
- W2005202278 cites W2056944665 @default.
- W2005202278 cites W2058313885 @default.
- W2005202278 cites W2065190583 @default.
- W2005202278 cites W2092356890 @default.
- W2005202278 cites W2093374391 @default.
- W2005202278 cites W2095828172 @default.
- W2005202278 cites W2103502613 @default.
- W2005202278 cites W2104227586 @default.
- W2005202278 cites W2109489224 @default.
- W2005202278 cites W2111243367 @default.
- W2005202278 cites W2111581233 @default.
- W2005202278 cites W2136250824 @default.
- W2005202278 cites W2137172917 @default.
- W2005202278 cites W2155624304 @default.
- W2005202278 cites W2156220037 @default.
- W2005202278 cites W2161905140 @default.
- W2005202278 cites W2170002980 @default.
- W2005202278 cites W2320084062 @default.
- W2005202278 cites W2417485231 @default.
- W2005202278 cites W2466055978 @default.
- W2005202278 cites W2883849285 @default.
- W2005202278 cites W62739187 @default.
- W2005202278 doi "https://doi.org/10.1001/archpsyc.1989.01810060064010" @default.
- W2005202278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2730278" @default.
- W2005202278 hasPublicationYear "1989" @default.
- W2005202278 type Work @default.
- W2005202278 sameAs 2005202278 @default.
- W2005202278 citedByCount "87" @default.
- W2005202278 countsByYear W20052022782012 @default.
- W2005202278 countsByYear W20052022782013 @default.
- W2005202278 countsByYear W20052022782021 @default.
- W2005202278 countsByYear W20052022782022 @default.
- W2005202278 crossrefType "journal-article" @default.
- W2005202278 hasAuthorship W2005202278A5071373873 @default.
- W2005202278 hasConcept C126322002 @default.
- W2005202278 hasConcept C134018914 @default.
- W2005202278 hasConcept C142724271 @default.
- W2005202278 hasConcept C15744967 @default.
- W2005202278 hasConcept C170493617 @default.
- W2005202278 hasConcept C204787440 @default.
- W2005202278 hasConcept C27081682 @default.
- W2005202278 hasConcept C2775864247 @default.
- W2005202278 hasConcept C2778938600 @default.
- W2005202278 hasConcept C2779134260 @default.
- W2005202278 hasConcept C2909992730 @default.
- W2005202278 hasConcept C502032728 @default.
- W2005202278 hasConcept C53910766 @default.
- W2005202278 hasConcept C71924100 @default.
- W2005202278 hasConceptScore W2005202278C126322002 @default.
- W2005202278 hasConceptScore W2005202278C134018914 @default.
- W2005202278 hasConceptScore W2005202278C142724271 @default.
- W2005202278 hasConceptScore W2005202278C15744967 @default.
- W2005202278 hasConceptScore W2005202278C170493617 @default.
- W2005202278 hasConceptScore W2005202278C204787440 @default.
- W2005202278 hasConceptScore W2005202278C27081682 @default.
- W2005202278 hasConceptScore W2005202278C2775864247 @default.
- W2005202278 hasConceptScore W2005202278C2778938600 @default.
- W2005202278 hasConceptScore W2005202278C2779134260 @default.
- W2005202278 hasConceptScore W2005202278C2909992730 @default.
- W2005202278 hasConceptScore W2005202278C502032728 @default.
- W2005202278 hasConceptScore W2005202278C53910766 @default.
- W2005202278 hasConceptScore W2005202278C71924100 @default.