Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005205210> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2005205210 endingPage "1345" @default.
- W2005205210 startingPage "1345" @default.
- W2005205210 abstract "To investigate the differential phosphorylation and activation of p38 in hepatocytes by pro-apoptotic Transforming Growth Factor-beta1 (TGF-beta1), pro-survival factors Epidermal Growth Factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) and the potential mechanisms.The phosphorylation and activation of p38 were determined by immunoblotting. Apoptosis was analyzed by morphological staining and observation, FACS analysis of sub-G1 content and DNA fragmentation assay. To quantitatively determine caspase activation, caspase activity assay was performed in vitro.TGF-beta1-induced apoptosis was associated with the phosphorylation of p38, and SB202190, a specific inhibitor of p38, which was able to inhibit TGF-beta1-induced caspase activation and apoptosis. TPA and EGF also blocked apoptosis induced by TGF-beta1. Both of them induced the phosphorylation of p38. The results showed SB202190 had no effect on TGF-beta1-induced phosphorylation of p38, but effectively inhibited both EGF and TPA-induced phosphorylation of p38.Pro-apoptotic TGF-beta1, anti-apoptotic TPA and EGF induce the phosphorylation of p38 through different mechanisms that can be distinguished by SB202190. The data suggest that TPA and EGF-induced p38 phosphorylation is through an autophosphorylation-dependent mechanism. Since p38 phosphorylation induced by TGF-beta1 plays an important role in caspase activation and apoptosis, TPA and EGF-induced p38 phosphorylation may not be requisite for their anti-apoptotic function." @default.
- W2005205210 created "2016-06-24" @default.
- W2005205210 creator A5006873847 @default.
- W2005205210 creator A5030315867 @default.
- W2005205210 date "2005-01-01" @default.
- W2005205210 modified "2023-10-16" @default.
- W2005205210 title "Differential phosphorylation of p38 induced by apoptotic and anti-apoptotic stimuli in murine hepatocytes" @default.
- W2005205210 cites W1511698983 @default.
- W2005205210 cites W1663371441 @default.
- W2005205210 cites W1745634660 @default.
- W2005205210 cites W1751748906 @default.
- W2005205210 cites W1831558236 @default.
- W2005205210 cites W1992199975 @default.
- W2005205210 cites W1994018922 @default.
- W2005205210 cites W1997656209 @default.
- W2005205210 cites W2005792688 @default.
- W2005205210 cites W2008693250 @default.
- W2005205210 cites W2009228099 @default.
- W2005205210 cites W2029354317 @default.
- W2005205210 cites W2034184306 @default.
- W2005205210 cites W2039259459 @default.
- W2005205210 cites W2046848104 @default.
- W2005205210 cites W2055662136 @default.
- W2005205210 cites W2076439289 @default.
- W2005205210 cites W2085791588 @default.
- W2005205210 cites W2094197406 @default.
- W2005205210 cites W2113989947 @default.
- W2005205210 cites W2137809122 @default.
- W2005205210 cites W4238530569 @default.
- W2005205210 cites W864620230 @default.
- W2005205210 doi "https://doi.org/10.3748/wjg.v11.i9.1345" @default.
- W2005205210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4250682" @default.
- W2005205210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15761973" @default.
- W2005205210 hasPublicationYear "2005" @default.
- W2005205210 type Work @default.
- W2005205210 sameAs 2005205210 @default.
- W2005205210 citedByCount "7" @default.
- W2005205210 countsByYear W20052052102013 @default.
- W2005205210 countsByYear W20052052102014 @default.
- W2005205210 countsByYear W20052052102019 @default.
- W2005205210 countsByYear W20052052102021 @default.
- W2005205210 crossrefType "journal-article" @default.
- W2005205210 hasAuthorship W2005205210A5006873847 @default.
- W2005205210 hasAuthorship W2005205210A5030315867 @default.
- W2005205210 hasBestOaLocation W20052052101 @default.
- W2005205210 hasConcept C11960822 @default.
- W2005205210 hasConcept C12519072 @default.
- W2005205210 hasConcept C150109051 @default.
- W2005205210 hasConcept C153911025 @default.
- W2005205210 hasConcept C170493617 @default.
- W2005205210 hasConcept C185592680 @default.
- W2005205210 hasConcept C190283241 @default.
- W2005205210 hasConcept C2776362946 @default.
- W2005205210 hasConcept C31573885 @default.
- W2005205210 hasConcept C43759708 @default.
- W2005205210 hasConcept C51551487 @default.
- W2005205210 hasConcept C55493867 @default.
- W2005205210 hasConcept C86803240 @default.
- W2005205210 hasConcept C87439868 @default.
- W2005205210 hasConcept C95444343 @default.
- W2005205210 hasConcept C97029542 @default.
- W2005205210 hasConceptScore W2005205210C11960822 @default.
- W2005205210 hasConceptScore W2005205210C12519072 @default.
- W2005205210 hasConceptScore W2005205210C150109051 @default.
- W2005205210 hasConceptScore W2005205210C153911025 @default.
- W2005205210 hasConceptScore W2005205210C170493617 @default.
- W2005205210 hasConceptScore W2005205210C185592680 @default.
- W2005205210 hasConceptScore W2005205210C190283241 @default.
- W2005205210 hasConceptScore W2005205210C2776362946 @default.
- W2005205210 hasConceptScore W2005205210C31573885 @default.
- W2005205210 hasConceptScore W2005205210C43759708 @default.
- W2005205210 hasConceptScore W2005205210C51551487 @default.
- W2005205210 hasConceptScore W2005205210C55493867 @default.
- W2005205210 hasConceptScore W2005205210C86803240 @default.
- W2005205210 hasConceptScore W2005205210C87439868 @default.
- W2005205210 hasConceptScore W2005205210C95444343 @default.
- W2005205210 hasConceptScore W2005205210C97029542 @default.
- W2005205210 hasIssue "9" @default.
- W2005205210 hasLocation W20052052101 @default.
- W2005205210 hasLocation W20052052102 @default.
- W2005205210 hasLocation W20052052103 @default.
- W2005205210 hasOpenAccess W2005205210 @default.
- W2005205210 hasPrimaryLocation W20052052101 @default.
- W2005205210 hasRelatedWork W1966981947 @default.
- W2005205210 hasRelatedWork W1968673729 @default.
- W2005205210 hasRelatedWork W1996044582 @default.
- W2005205210 hasRelatedWork W2043358826 @default.
- W2005205210 hasRelatedWork W2048110853 @default.
- W2005205210 hasRelatedWork W2076096585 @default.
- W2005205210 hasRelatedWork W2352517883 @default.
- W2005205210 hasRelatedWork W242815716 @default.
- W2005205210 hasRelatedWork W3028704232 @default.
- W2005205210 hasRelatedWork W4220681557 @default.
- W2005205210 hasVolume "11" @default.
- W2005205210 isParatext "false" @default.
- W2005205210 isRetracted "false" @default.
- W2005205210 magId "2005205210" @default.
- W2005205210 workType "article" @default.