Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005222712> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2005222712 endingPage "464" @default.
- W2005222712 startingPage "451" @default.
- W2005222712 abstract "Summary Oroxylin A (5,7-dihydroxy-6-methoxyflavone), which has showed multiple pharmacological effects, was semi-synthesized chemically as a pharmaceutical agent. Its impurities, degradation products and their formation pathways remain unknown. In the present study, two impurities (5,6,7-trihydroxyflavone, 5-hydroxy-6,7-dimethoxytlavone) and a degradation product (5,7-dihydroxy-8-methoxyflavone) in Oroxylin A bulk drug substance were identified, and their formation pathways were proposed. A reversed phase liquid chromatographic method for the simultaneous determination of Oroxylin A and the three compounds was developed on a C18 column using methanol-acetonitrile-0.1% acetic acid (54:23:23, v/v/v) as the mobile phase. The detection was performed at 271 nm. The method was validated to be robust, precise, specific and linear between 4 and 40 μg mL−1; the limits of detection and quantification of Oroxylin A were 0.01 and 0.04 μg mL−1, respectively. The developed method was found to be suitable to check the quality of bulk samples of Oroxylin A at the time of batch release and also during its stability studies (long term and accelerated stability)." @default.
- W2005222712 created "2016-06-24" @default.
- W2005222712 creator A5025450470 @default.
- W2005222712 creator A5034237150 @default.
- W2005222712 creator A5035548891 @default.
- W2005222712 creator A5042203927 @default.
- W2005222712 creator A5075942591 @default.
- W2005222712 date "2013-09-01" @default.
- W2005222712 modified "2023-09-27" @default.
- W2005222712 title "A study of impurities and degradation products in Oroxylin A by a validated liquid chromatographic method with analysis of their formation pathways" @default.
- W2005222712 cites W1964311344 @default.
- W2005222712 cites W1991576415 @default.
- W2005222712 cites W1999799807 @default.
- W2005222712 cites W2014024345 @default.
- W2005222712 cites W2030216143 @default.
- W2005222712 cites W2066030021 @default.
- W2005222712 cites W2071230988 @default.
- W2005222712 cites W2073677430 @default.
- W2005222712 cites W2076275533 @default.
- W2005222712 cites W2093051812 @default.
- W2005222712 cites W2169410808 @default.
- W2005222712 cites W4323053945 @default.
- W2005222712 doi "https://doi.org/10.1556/achrom.25.2013.3.4" @default.
- W2005222712 hasPublicationYear "2013" @default.
- W2005222712 type Work @default.
- W2005222712 sameAs 2005222712 @default.
- W2005222712 citedByCount "0" @default.
- W2005222712 crossrefType "journal-article" @default.
- W2005222712 hasAuthorship W2005222712A5025450470 @default.
- W2005222712 hasAuthorship W2005222712A5034237150 @default.
- W2005222712 hasAuthorship W2005222712A5035548891 @default.
- W2005222712 hasAuthorship W2005222712A5042203927 @default.
- W2005222712 hasAuthorship W2005222712A5075942591 @default.
- W2005222712 hasBestOaLocation W20052227121 @default.
- W2005222712 hasConcept C178790620 @default.
- W2005222712 hasConcept C179998833 @default.
- W2005222712 hasConcept C185592680 @default.
- W2005222712 hasConcept C2776673659 @default.
- W2005222712 hasConcept C2777463227 @default.
- W2005222712 hasConcept C2777682752 @default.
- W2005222712 hasConcept C2779607525 @default.
- W2005222712 hasConcept C2779679103 @default.
- W2005222712 hasConcept C2992520659 @default.
- W2005222712 hasConcept C41008148 @default.
- W2005222712 hasConcept C43617362 @default.
- W2005222712 hasConcept C45188465 @default.
- W2005222712 hasConcept C55493867 @default.
- W2005222712 hasConcept C71987851 @default.
- W2005222712 hasConcept C76155785 @default.
- W2005222712 hasConceptScore W2005222712C178790620 @default.
- W2005222712 hasConceptScore W2005222712C179998833 @default.
- W2005222712 hasConceptScore W2005222712C185592680 @default.
- W2005222712 hasConceptScore W2005222712C2776673659 @default.
- W2005222712 hasConceptScore W2005222712C2777463227 @default.
- W2005222712 hasConceptScore W2005222712C2777682752 @default.
- W2005222712 hasConceptScore W2005222712C2779607525 @default.
- W2005222712 hasConceptScore W2005222712C2779679103 @default.
- W2005222712 hasConceptScore W2005222712C2992520659 @default.
- W2005222712 hasConceptScore W2005222712C41008148 @default.
- W2005222712 hasConceptScore W2005222712C43617362 @default.
- W2005222712 hasConceptScore W2005222712C45188465 @default.
- W2005222712 hasConceptScore W2005222712C55493867 @default.
- W2005222712 hasConceptScore W2005222712C71987851 @default.
- W2005222712 hasConceptScore W2005222712C76155785 @default.
- W2005222712 hasIssue "3" @default.
- W2005222712 hasLocation W20052227121 @default.
- W2005222712 hasOpenAccess W2005222712 @default.
- W2005222712 hasPrimaryLocation W20052227121 @default.
- W2005222712 hasRelatedWork W1511678538 @default.
- W2005222712 hasRelatedWork W1987713971 @default.
- W2005222712 hasRelatedWork W1990352258 @default.
- W2005222712 hasRelatedWork W2018862250 @default.
- W2005222712 hasRelatedWork W2037953849 @default.
- W2005222712 hasRelatedWork W2085532134 @default.
- W2005222712 hasRelatedWork W2087046738 @default.
- W2005222712 hasRelatedWork W2089660391 @default.
- W2005222712 hasRelatedWork W2256031060 @default.
- W2005222712 hasRelatedWork W3196720140 @default.
- W2005222712 hasVolume "25" @default.
- W2005222712 isParatext "false" @default.
- W2005222712 isRetracted "false" @default.
- W2005222712 magId "2005222712" @default.
- W2005222712 workType "article" @default.