FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005223000> ?p ?o ?g. }

• W2005223000 endingPage "5162" @default.
• W2005223000 startingPage "5151" @default.
• W2005223000 abstract "High mobility group box 1 (HMGB1) is a 25-kDa chromatin-associated protein that aids in transcription and DNA repair by directly binding to DNA and altering its conformation. Additionally, HMGB1 can act as an extracellular ligand. When released from dying or stressed cells, HMGB1 binds to the RAGE receptor and activates the p42/44 MAP kinase (MAPK) cascade. HMGB1 is overexpressed in many types of cancer and frequently associated with tumor stage and metastasis. This has predominantly been attributed to an autocrine function that drives MAPK pathway activity. However, by using tumor cells with activating MAPK pathway mutations, we have identified a role for HMGB1 in promoting metastasis and tumor growth that is independent of this pathway. In the absence of HMGB1, these tumor cells show defective in vitro migration as well as reduced metastasis and tumor growth in vivo despite high p42/44 phosphorylation. We found that semaphorin 3A (SEMA3A), previously shown to act as a suppressor of angiogenesis and migration, was highly increased during expression in the absence of HMGB1. SEMA3A/HMGB1 double knockdown rescued the migration defect in HMGB1 single knockdown cells. HMGB1 bound at the semaphorin 3A genomic locus, promoted hetrochromatin formation, and decreased occupancy of acetylated histones. Based on human tumor gene expression databases, HMGB1 was significantly inversely correlated with SEMA3A, suggesting that this mechanism may be more widely relevant in different cancer types." @default.
• W2005223000 created "2016-06-24" @default.
• W2005223000 creator A5032101132 @default.
• W2005223000 creator A5053242094 @default.
• W2005223000 creator A5055802741 @default.
• W2005223000 creator A5082685256 @default.
• W2005223000 date "2013-11-11" @default.
• W2005223000 modified "2023-10-18" @default.
• W2005223000 title "High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A" @default.
• W2005223000 cites W1524615273 @default.
• W2005223000 cites W1549539592 @default.
• W2005223000 cites W1980228385 @default.
• W2005223000 cites W1982935125 @default.
• W2005223000 cites W1986686737 @default.
• W2005223000 cites W1988626539 @default.
• W2005223000 cites W2001546115 @default.
• W2005223000 cites W2016000295 @default.
• W2005223000 cites W2016451424 @default.
• W2005223000 cites W2020203901 @default.
• W2005223000 cites W2026920505 @default.
• W2005223000 cites W2034159685 @default.
• W2005223000 cites W2044737524 @default.
• W2005223000 cites W2049685233 @default.
• W2005223000 cites W2057151160 @default.
• W2005223000 cites W2066452507 @default.
• W2005223000 cites W2073676627 @default.
• W2005223000 cites W2086146050 @default.
• W2005223000 cites W2092021778 @default.
• W2005223000 cites W2101153911 @default.
• W2005223000 cites W2105556644 @default.
• W2005223000 cites W2109633639 @default.
• W2005223000 cites W2111291314 @default.
• W2005223000 cites W2115293825 @default.
• W2005223000 cites W2123200599 @default.
• W2005223000 cites W2123328403 @default.
• W2005223000 cites W2133538902 @default.
• W2005223000 cites W2139680138 @default.
• W2005223000 cites W2142730895 @default.
• W2005223000 cites W2147426561 @default.
• W2005223000 cites W2155740016 @default.
• W2005223000 cites W2155756882 @default.
• W2005223000 cites W2156617360 @default.
• W2005223000 cites W2162900484 @default.
• W2005223000 doi "https://doi.org/10.1038/onc.2013.459" @default.
• W2005223000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24213571" @default.
• W2005223000 hasPublicationYear "2013" @default.
• W2005223000 type Work @default.
• W2005223000 sameAs 2005223000 @default.
• W2005223000 citedByCount "20" @default.
• W2005223000 countsByYear W20052230002014 @default.
• W2005223000 countsByYear W20052230002015 @default.
• W2005223000 countsByYear W20052230002016 @default.
• W2005223000 countsByYear W20052230002017 @default.
• W2005223000 countsByYear W20052230002018 @default.
• W2005223000 countsByYear W20052230002019 @default.
• W2005223000 countsByYear W20052230002021 @default.
• W2005223000 countsByYear W20052230002022 @default.
• W2005223000 crossrefType "journal-article" @default.
• W2005223000 hasAuthorship W2005223000A5032101132 @default.
• W2005223000 hasAuthorship W2005223000A5053242094 @default.
• W2005223000 hasAuthorship W2005223000A5055802741 @default.
• W2005223000 hasAuthorship W2005223000A5082685256 @default.
• W2005223000 hasBestOaLocation W20052230001 @default.
• W2005223000 hasConcept C104317684 @default.
• W2005223000 hasConcept C119056186 @default.
• W2005223000 hasConcept C132538176 @default.
• W2005223000 hasConcept C137738243 @default.
• W2005223000 hasConcept C170493617 @default.
• W2005223000 hasConcept C173396325 @default.
• W2005223000 hasConcept C184235292 @default.
• W2005223000 hasConcept C2776805952 @default.
• W2005223000 hasConcept C2780545709 @default.
• W2005223000 hasConcept C502942594 @default.
• W2005223000 hasConcept C54355233 @default.
• W2005223000 hasConcept C57074206 @default.
• W2005223000 hasConcept C81885089 @default.
• W2005223000 hasConcept C83640560 @default.
• W2005223000 hasConcept C86803240 @default.
• W2005223000 hasConcept C95444343 @default.
• W2005223000 hasConceptScore W2005223000C104317684 @default.
• W2005223000 hasConceptScore W2005223000C119056186 @default.
• W2005223000 hasConceptScore W2005223000C132538176 @default.
• W2005223000 hasConceptScore W2005223000C137738243 @default.
• W2005223000 hasConceptScore W2005223000C170493617 @default.
• W2005223000 hasConceptScore W2005223000C173396325 @default.
• W2005223000 hasConceptScore W2005223000C184235292 @default.
• W2005223000 hasConceptScore W2005223000C2776805952 @default.
• W2005223000 hasConceptScore W2005223000C2780545709 @default.
• W2005223000 hasConceptScore W2005223000C502942594 @default.
• W2005223000 hasConceptScore W2005223000C54355233 @default.
• W2005223000 hasConceptScore W2005223000C57074206 @default.
• W2005223000 hasConceptScore W2005223000C81885089 @default.
• W2005223000 hasConceptScore W2005223000C83640560 @default.
• W2005223000 hasConceptScore W2005223000C86803240 @default.
• W2005223000 hasConceptScore W2005223000C95444343 @default.
• W2005223000 hasIssue "44" @default.
• W2005223000 hasLocation W20052230001 @default.
• W2005223000 hasLocation W20052230002 @default.

• next