FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005230066> ?p ?o ?g. }

• W2005230066 endingPage "1026" @default.
• W2005230066 startingPage "1021" @default.
• W2005230066 abstract "Between 2/87 and 2/91, 49 women with operable breast cancer involving greater than or equal to 10 axillary nodes were treated following mastectomy, with four cycles of Cyclophosphamide, Adriamycin, 5FU, followed by high doses of Cyclophosphamide, Cisplatin, Carmustine (HDCT) with autologous bone marrow transplant support. Forty patients received local-regional radiotherapy (generally to the chest wall, internal mammary, supraclavicular, +/- axillary nodal areas; minimum 44-50 Gy, 1.8-2 Gy/fraction, +/- 10-15 Gy scar boost; standard radiation techniques). The first nine patients did not receive local-regional radiotherapy. Three developed a local-regional failure (6-12 months after HDCT); six are without evidence of disease. Local-regional radiotherapy (LR XRT) was delivered to the subsequent 40 patients following HDCT+autologous bone marrow transplant. Six received less than 44 Gy of the planned local-regional radiotherapy due to significant toxicity and one of these failed locally. Only one local failure was observed among the 34 patients who received greater than or equal to 44 Gy. Two additional patients developed distant metastases. None of these 40 patients have failed in the axilla despite the fact that the axilla was irradiated in only 18 cases. Overall, 36/40 (90%) of these patients are without evidence of disease 4-30 months following HDCT (approximately 10-36 months after mastectomy, median 22 months). Radiotherapy was interrupted or discontinued because of progressive dyspnea, thrombocytopenia, or neutropenia in nine patients. Further studies to determine the roles of local-regional radiotherapy and HDCT in the development of these toxicities are underway. These encouraging results suggest that HDCT + autologous bone marrow transplant+local-regional radiotherapy may improve the survival rate in these high risk patients. A national randomized study to test the efficacy of this HDCT regimen is currently underway (Cancer and Leukemia Group B#9082 and Southwest Oncology Group #9114)." @default.
• W2005230066 created "2016-06-24" @default.
• W2005230066 creator A5007801126 @default.
• W2005230066 creator A5014505996 @default.
• W2005230066 creator A5014552831 @default.
• W2005230066 creator A5029186084 @default.
• W2005230066 creator A5042596874 @default.
• W2005230066 creator A5085526628 @default.
• W2005230066 creator A5085651347 @default.
• W2005230066 date "1992-01-01" @default.
• W2005230066 modified "2023-10-02" @default.
• W2005230066 title "Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with ≥ 10 positive axillary lymph nodes" @default.
• W2005230066 cites W1820052401 @default.
• W2005230066 cites W1835459135 @default.
• W2005230066 cites W1842248410 @default.
• W2005230066 cites W1899541887 @default.
• W2005230066 cites W1972083432 @default.
• W2005230066 cites W1982782438 @default.
• W2005230066 cites W1994215944 @default.
• W2005230066 cites W2015188154 @default.
• W2005230066 cites W2029440267 @default.
• W2005230066 cites W2034458867 @default.
• W2005230066 cites W2051155200 @default.
• W2005230066 cites W2055297497 @default.
• W2005230066 cites W2055798764 @default.
• W2005230066 cites W2074807580 @default.
• W2005230066 cites W2083616014 @default.
• W2005230066 cites W2086869132 @default.
• W2005230066 cites W2090957223 @default.
• W2005230066 cites W2094144860 @default.
• W2005230066 cites W2100329719 @default.
• W2005230066 cites W2276085691 @default.
• W2005230066 cites W2289675002 @default.
• W2005230066 doi "https://doi.org/10.1016/0360-3016(92)90908-z" @default.
• W2005230066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1639635" @default.
• W2005230066 hasPublicationYear "1992" @default.
• W2005230066 type Work @default.
• W2005230066 sameAs 2005230066 @default.
• W2005230066 citedByCount "104" @default.
• W2005230066 countsByYear W20052300662012 @default.
• W2005230066 countsByYear W20052300662013 @default.
• W2005230066 countsByYear W20052300662016 @default.
• W2005230066 countsByYear W20052300662017 @default.
• W2005230066 countsByYear W20052300662019 @default.
• W2005230066 crossrefType "journal-article" @default.
• W2005230066 hasAuthorship W2005230066A5007801126 @default.
• W2005230066 hasAuthorship W2005230066A5014505996 @default.
• W2005230066 hasAuthorship W2005230066A5014552831 @default.
• W2005230066 hasAuthorship W2005230066A5029186084 @default.
• W2005230066 hasAuthorship W2005230066A5042596874 @default.
• W2005230066 hasAuthorship W2005230066A5085526628 @default.
• W2005230066 hasAuthorship W2005230066A5085651347 @default.
• W2005230066 hasConcept C121608353 @default.
• W2005230066 hasConcept C126322002 @default.
• W2005230066 hasConcept C141071460 @default.
• W2005230066 hasConcept C2776608951 @default.
• W2005230066 hasConcept C2776694085 @default.
• W2005230066 hasConcept C2776755627 @default.
• W2005230066 hasConcept C2777649267 @default.
• W2005230066 hasConcept C2777757722 @default.
• W2005230066 hasConcept C509974204 @default.
• W2005230066 hasConcept C530470458 @default.
• W2005230066 hasConcept C71924100 @default.
• W2005230066 hasConceptScore W2005230066C121608353 @default.
• W2005230066 hasConceptScore W2005230066C126322002 @default.
• W2005230066 hasConceptScore W2005230066C141071460 @default.
• W2005230066 hasConceptScore W2005230066C2776608951 @default.
• W2005230066 hasConceptScore W2005230066C2776694085 @default.
• W2005230066 hasConceptScore W2005230066C2776755627 @default.
• W2005230066 hasConceptScore W2005230066C2777649267 @default.
• W2005230066 hasConceptScore W2005230066C2777757722 @default.
• W2005230066 hasConceptScore W2005230066C509974204 @default.
• W2005230066 hasConceptScore W2005230066C530470458 @default.
• W2005230066 hasConceptScore W2005230066C71924100 @default.
• W2005230066 hasIssue "5" @default.
• W2005230066 hasLocation W20052300661 @default.
• W2005230066 hasLocation W20052300662 @default.
• W2005230066 hasOpenAccess W2005230066 @default.
• W2005230066 hasPrimaryLocation W20052300661 @default.
• W2005230066 hasRelatedWork W2005230066 @default.
• W2005230066 hasRelatedWork W2010740545 @default.
• W2005230066 hasRelatedWork W2019694656 @default.
• W2005230066 hasRelatedWork W2073937368 @default.
• W2005230066 hasRelatedWork W2365277249 @default.
• W2005230066 hasRelatedWork W2466949046 @default.
• W2005230066 hasRelatedWork W3030082946 @default.
• W2005230066 hasRelatedWork W304623792 @default.
• W2005230066 hasRelatedWork W4214554217 @default.
• W2005230066 hasRelatedWork W4249268874 @default.
• W2005230066 hasVolume "23" @default.
• W2005230066 isParatext "false" @default.
• W2005230066 isRetracted "false" @default.
• W2005230066 magId "2005230066" @default.
• W2005230066 workType "article" @default.