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• W2005233776 abstract "In mouse hepatoma cells, both the regulatory and the transcribed regions of the cyp1a1 gene assume a nucleosomal configuration when the gene is silent; two nucleosomes occupy specific sites at the transcriptional promoter. Activation of transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is accompanied by changes in chromatin structure, which depend upon a functional aromatic hydrocarbon (Ah) receptor. In the transcribed region of the gene, nucleosome disruption occurs as a consequence of RNA elongation. In contrast, at the promoter, loss of positioned nucleosome sis independent of transcription and represents an event in the mechanism by which the liganded Ah receptor enhances transcriptional initiation." @default.
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• W2005233776 date "1992-12-01" @default.
• W2005233776 modified "2023-10-14" @default.
• W2005233776 title "Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin." @default.
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• W2005233776 doi "https://doi.org/10.1073/pnas.89.23.11622" @default.
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