FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005236521> ?p ?o ?g. }

• W2005236521 endingPage "600" @default.
• W2005236521 startingPage "587" @default.
• W2005236521 abstract "The Male-Specific Lethal (MSL) complex regulates dosage compensation of the male X chromosome in Drosophila. Here, we report the crystal structure of its MSL1/MSL2 core, where two MSL2 subunits bind to a dimer formed by two molecules of MSL1. Analysis of structure-based mutants revealed that MSL2 can only interact with the MSL1 dimer, but MSL1 dimerization is MSL2 independent. We show that Msl1 is a substrate for Msl2 E3 ubiquitin ligase activity. ChIP experiments revealed that Msl1 dimerization is essential for targeting and spreading of the MSL complex on X-linked genes; however, Msl1 binding to promoters of male and female cells is independent of the dimer status and other MSL proteins. Finally, we show that loss of Msl1 dimerization leads to male-specific lethality. We propose that Msl1-mediated dimerization of the entire MSL complex is required for Msl2 binding, X chromosome recognition, and spreading along the X chromosome." @default.
• W2005236521 created "2016-06-24" @default.
• W2005236521 creator A5004579909 @default.
• W2005236521 creator A5015702014 @default.
• W2005236521 creator A5036399862 @default.
• W2005236521 creator A5041870481 @default.
• W2005236521 creator A5049150899 @default.
• W2005236521 creator A5060345195 @default.
• W2005236521 creator A5091138640 @default.
• W2005236521 date "2012-11-01" @default.
• W2005236521 modified "2023-10-13" @default.
• W2005236521 title "Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila" @default.
• W2005236521 cites W1479721949 @default.
• W2005236521 cites W1500148822 @default.
• W2005236521 cites W1902704112 @default.
• W2005236521 cites W1967985251 @default.
• W2005236521 cites W1968085402 @default.
• W2005236521 cites W1973246213 @default.
• W2005236521 cites W1992885695 @default.
• W2005236521 cites W1994286350 @default.
• W2005236521 cites W2002658922 @default.
• W2005236521 cites W2003959153 @default.
• W2005236521 cites W2006229889 @default.
• W2005236521 cites W2015291446 @default.
• W2005236521 cites W2022503985 @default.
• W2005236521 cites W2031228008 @default.
• W2005236521 cites W2035071275 @default.
• W2005236521 cites W2035487814 @default.
• W2005236521 cites W2038968612 @default.
• W2005236521 cites W2041769998 @default.
• W2005236521 cites W2045177535 @default.
• W2005236521 cites W2047607345 @default.
• W2005236521 cites W2048320911 @default.
• W2005236521 cites W2059282068 @default.
• W2005236521 cites W2060958959 @default.
• W2005236521 cites W2073486860 @default.
• W2005236521 cites W2076566576 @default.
• W2005236521 cites W2077968912 @default.
• W2005236521 cites W2079081965 @default.
• W2005236521 cites W2079635700 @default.
• W2005236521 cites W2081324839 @default.
• W2005236521 cites W2086399711 @default.
• W2005236521 cites W2090191263 @default.
• W2005236521 cites W2102544634 @default.
• W2005236521 cites W2104582907 @default.
• W2005236521 cites W2105023165 @default.
• W2005236521 cites W2116196682 @default.
• W2005236521 cites W2129105252 @default.
• W2005236521 cites W2134216529 @default.
• W2005236521 cites W2140450002 @default.
• W2005236521 cites W2148400226 @default.
• W2005236521 cites W2155941594 @default.
• W2005236521 cites W2161074428 @default.
• W2005236521 cites W2551589685 @default.
• W2005236521 cites W307582 @default.
• W2005236521 doi "https://doi.org/10.1016/j.molcel.2012.09.014" @default.
• W2005236521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23084835" @default.
• W2005236521 hasPublicationYear "2012" @default.
• W2005236521 type Work @default.
• W2005236521 sameAs 2005236521 @default.
• W2005236521 citedByCount "42" @default.
• W2005236521 countsByYear W20052365212013 @default.
• W2005236521 countsByYear W20052365212014 @default.
• W2005236521 countsByYear W20052365212015 @default.
• W2005236521 countsByYear W20052365212016 @default.
• W2005236521 countsByYear W20052365212017 @default.
• W2005236521 countsByYear W20052365212018 @default.
• W2005236521 countsByYear W20052365212019 @default.
• W2005236521 countsByYear W20052365212020 @default.
• W2005236521 countsByYear W20052365212021 @default.
• W2005236521 countsByYear W20052365212022 @default.
• W2005236521 countsByYear W20052365212023 @default.
• W2005236521 crossrefType "journal-article" @default.
• W2005236521 hasAuthorship W2005236521A5004579909 @default.
• W2005236521 hasAuthorship W2005236521A5015702014 @default.
• W2005236521 hasAuthorship W2005236521A5036399862 @default.
• W2005236521 hasAuthorship W2005236521A5041870481 @default.
• W2005236521 hasAuthorship W2005236521A5049150899 @default.
• W2005236521 hasAuthorship W2005236521A5060345195 @default.
• W2005236521 hasAuthorship W2005236521A5091138640 @default.
• W2005236521 hasBestOaLocation W20052365211 @default.
• W2005236521 hasConcept C104317684 @default.
• W2005236521 hasConcept C121332964 @default.
• W2005236521 hasConcept C134459356 @default.
• W2005236521 hasConcept C143065580 @default.
• W2005236521 hasConcept C175114707 @default.
• W2005236521 hasConcept C25602115 @default.
• W2005236521 hasConcept C2776041557 @default.
• W2005236521 hasConcept C2779546866 @default.
• W2005236521 hasConcept C30481170 @default.
• W2005236521 hasConcept C35158069 @default.
• W2005236521 hasConcept C4323932 @default.
• W2005236521 hasConcept C46141821 @default.
• W2005236521 hasConcept C54355233 @default.
• W2005236521 hasConcept C86803240 @default.
• W2005236521 hasConcept C92509807 @default.
• W2005236521 hasConcept C95444343 @default.
• W2005236521 hasConceptScore W2005236521C104317684 @default.

• next