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- W2005237316 abstract "Abstract The safety evaluation of chlorhexidine (Hibitane) in animal species will be briefly reviewed. The relevance of these studies to human use will be discussed, and species comparisons made where possible. Animal studies with chlorhexidine were begun more than two decades ago and the evaluation of its safety has been under continual review ever since. Chlorhexidine is poorly absorbed after oral administration, well tolerated after parenteral administration and its percutaneous absorption is absolutely minimal. No clinical or histological effects have been obtained in any animal study to cause hesitation in the light of proliferating applications of chlorhexidine in human use. The various lexicological studies in animals will be described and in particular the results of a 2-year study in rats will be outlined. In this, as in an earlier long-term study, there were no effects whatsoever to suggest that chlorhexidine treatment could give rise to any kind of tumourigenic effect or any other toxic sign." @default.
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- W2005237316 date "1977-12-01" @default.
- W2005237316 modified "2023-09-24" @default.
- W2005237316 title "Safety of Hibitane I. Laboratory experiments" @default.
- W2005237316 cites W2119882866 @default.
- W2005237316 doi "https://doi.org/10.1111/j.1600-051x.1977.tb00052.x" @default.
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