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- W2005238462 abstract "Introduction: Cardiac synchronization therapy (CRT) helps synchronize right and left ventricles (RV, LV) and improve cardiac function in patients (pts) with heart failure. This study was to determine if electrical cardiac contractility modulation (CCM) on top of bi-ventricular (BiV) pacing would provide additional LV mechanical improvement.Methods: 16 Pts receiving CRT-ICD device were enrolled (LVEF: 30±6%, QRS width: 170±22 ms, all with beta-blocker therapy). After the leads were placed in RV and LV for CRT, the leads were connected to an EP stimulator for acutely delivering CCM. The CCM with three electrical pulses (8V, 5 msec/pulse, 10 msec inter-pulse interval) was delivered 30 msec after local sensing or BiV pacing. There were four types of CCM delivering: CCM at the local LV pacing site during intrinsic rhythm (test 1), at the local LV pacing site during BiV pacing (test 2), at the local RV pacing site during intrinsic rhythm (test 3), and simultaneously at LV and RV during BiV pacing (test 4). An LV pressure catheter was introduced into the LV chamber for pressure recording and pressure dp/dtmax analysis. Comparisons were performed between the LV dp/dtmax at baseline without CCM and that during the CCM tests.Results: In the table, there was no improvement in the LV dp/dtmax when CCM was delivered locally (tests 1 and 2) or RV region (test 3). When CCM was delivered simultaneously at the RV and LV during BiV pacing (test 4), the LV dp/dtmax was significantly improved by 9.5%. The averaged maximum improvement (%) of LV dp/dtmax from 4 tests in each patient was 14.3±11.8%.View this table:LV dp/dtmax during CCM in four groupsConclusion: CCM, when delivered to both RV and LV, can improve LV mechanical function on top of BiV pacing, which may provide additional benefits for CRT patients, especially for CRT non-responders." @default.
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- W2005238462 date "2013-08-02" @default.
- W2005238462 modified "2023-10-12" @default.
- W2005238462 title "Electrical cardiac contractility modulation in CRT patients" @default.
- W2005238462 doi "https://doi.org/10.1093/eurheartj/eht309.p3208" @default.
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