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- W2005244518 endingPage "1280" @default.
- W2005244518 startingPage "1249" @default.
- W2005244518 abstract "I present a hypothesis that begins with the proposal that abiotic ancestors of phage RNA and DNA packaging systems (and cells) include mobile shells with an internal, molecule-transporting cavity. The foundations of this hypothesis include the conjecture that current nucleic acid packaging systems have imprints from abiotic ancestors. The abiotic shells (1) initially imbibe and later also bind and transport organic molecules, thereby providing a means for producing molecular interactions that are links in the chain of events that produces ancestors to the first molecules that are both information carrying and enzymatically active, and (2) are subsequently scaffolds on which proteins assemble to form ancestors common to both shells of viral capsids and cell membranes. Emergence of cells occurs via aggregation and merger of shells and internal contents. The hypothesis continues by using proposed imprints of abiotic and biotic ancestors to deduce an ancestral thermal ratchet-based DNA packaging motor that subsequently evolves to integrate a DNA packaging ATPase that provides a power stroke." @default.
- W2005244518 created "2016-06-24" @default.
- W2005244518 creator A5029918137 @default.
- W2005244518 date "2011-07-20" @default.
- W2005244518 modified "2023-09-23" @default.
- W2005244518 title "Proposed Ancestors of Phage Nucleic Acid Packaging Motors (and Cells)" @default.
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