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- W2005247029 abstract "There exists an ongoing debate about the functional relevance of the pre-supplementary motor area (pre-SMA) and right ventrolateral prefrontal cortex (VLPFC) for response inhibition during Stop signal task, because of difficulties in segregating cognitive elements involved in stopping, such as response inhibition, attentional control and error monitoring. To further understand the precise brain representation of response inhibition, we developed a new Double-press signal task that requires subjects to decide pressing the button once or twice as quickly as possible according to the cue and conducted an event-related functional MRI study of the conventional Stop signal and Double-press signal tasks for 13 healthy subjects. The advantage of our experimental design is that the latter task does not contain any response inhibition and that its difficulty measured by error rate is not significantly different from that of Stop signal task. Activations of the right VLPFC and pre-SMA were observed only for Stop signal task. Moreover, voxel-by-voxel analysis comparing these two tasks showed the significantly larger activation in the pre-SMA for Stop signal task, supporting the hypothesis that the pre-SMA is functionally essential for response inhibition." @default.
- W2005247029 created "2016-06-24" @default.
- W2005247029 creator A5013920139 @default.
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- W2005247029 creator A5061304175 @default.
- W2005247029 creator A5069997869 @default.
- W2005247029 creator A5090155022 @default.
- W2005247029 date "2011-07-01" @default.
- W2005247029 modified "2023-10-14" @default.
- W2005247029 title "Functional relevance of pre-supplementary motor areas for the choice to stop during Stop signal task" @default.
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