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- W2005260015 abstract "1. Tracer doses of uniformly 14C-labeled phytol were absorbed from the intestine of the rat to the extent of approx. 50% in 24 h. When the doses were increased to 300 mg, a smaller fraction was absorbed but the total quantity absorbed reached values as high as 65 mg. Over 70% of the absorbed phytol entered through the intestinal lymphatics. Phytol and cetyl alcohol were absorbed more slowly and less completely than were phytanic acid and palmitic acid, and less exclusively by way of the lymphatic route. 2. Over half of the [14C] phytol radioactivity absorbed into the thoracic-duct lymph was still in phytol, some of which was free but a larger part of which was in the form of phytyl esters of fatty acids. The remainder of the label was in acidic derivatives of phytol, principally phytanic acid and phytenic acid (probably at least 3 isomers), which were present almost entirely in triglycerides and other complex lipids. The same derivatives were found in germ-free rats. No dihydrophytol was found in the lymph after phytol had been fed, and no phytenic acid was found after phytanic acid had been fed. Administered phytanic acid was absorbed into the lymph largely without change, except for its incorporation into triglycerides and other complex lipids. In contrast to the results with phytol, cetyl alcohol was largely converted to fatty acid during absorption. 3. Significant quantities of radioactivity from [14C]phytol (administered to rats with intact thoracic ducts) were excreted in the bile, principally in the form of derivatives much more polar than phytanic acid." @default.
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- W2005260015 date "1967-04-01" @default.
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- W2005260015 title "Absorption and metabolism of uniformly 14C-labeled phytol and phytanic acid by the intestine of the rat studied with thoracic duct cannulation" @default.
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- W2005260015 doi "https://doi.org/10.1016/0005-2760(67)90103-8" @default.
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