Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005261503> ?p ?o ?g. }
- W2005261503 abstract "Granzyme B is the prototypic member of the granzymes, a family of trypsin-like serine proteinases localized in the dense cytoplasmic granules of activated natural killer cells and cytotoxic T lymphocytes. Granzyme B directly triggers apoptosis in target cells by activating the caspase pathway, and has been implicated in the etiology of rheumatoid arthritis. Human granzyme B expressed in a baculovirus system has been crystallized without inhibitor and its structure has been determined to 3.1 A resolution, after considerably improving the diffraction power of the crystals by controlled humidity changes. The granzyme B structure reveals an overall fold similar to that found in cathepsin G and human chymase. The guanidinium group of Arg226, anchored at the back of the S1-specificity pocket, can form a salt bridge with the P1-Asp side chain of a bound peptide substrate. The architecture of the substrate binding site of granzyme B appears to be designed to accommodate and cleave hexapeptides such as the sequence Ile-Glu-Thr-Asp-/Ser-Gly present in the activation site of pro-caspase-3, a proven physiological substrate of granzyme B. These granzyme B crystals, with fully accessible active sites, are well suited for soaking with small synthetic inhibitors that might be used for a treatment of chronic inflammatory disorders." @default.
- W2005261503 created "2016-06-24" @default.
- W2005261503 creator A5016898819 @default.
- W2005261503 creator A5036038504 @default.
- W2005261503 creator A5041040140 @default.
- W2005261503 creator A5051987821 @default.
- W2005261503 creator A5053305571 @default.
- W2005261503 creator A5061321693 @default.
- W2005261503 creator A5063495689 @default.
- W2005261503 creator A5065848878 @default.
- W2005261503 creator A5072138098 @default.
- W2005261503 date "2000-01-18" @default.
- W2005261503 modified "2023-09-23" @default.
- W2005261503 title "Crystal Structure of the Caspase Activator Human Granzyme B, a Proteinase Highly Specific for an Asp-P1 Residue" @default.
- W2005261503 cites W1499093538 @default.
- W2005261503 cites W1514372388 @default.
- W2005261503 cites W1539525020 @default.
- W2005261503 cites W1546719435 @default.
- W2005261503 cites W1549331588 @default.
- W2005261503 cites W1563964441 @default.
- W2005261503 cites W1587508560 @default.
- W2005261503 cites W1595615359 @default.
- W2005261503 cites W1595797136 @default.
- W2005261503 cites W173669577 @default.
- W2005261503 cites W1967912613 @default.
- W2005261503 cites W1971813119 @default.
- W2005261503 cites W1973909424 @default.
- W2005261503 cites W1977449349 @default.
- W2005261503 cites W1979323848 @default.
- W2005261503 cites W1984444278 @default.
- W2005261503 cites W1986191025 @default.
- W2005261503 cites W1993554383 @default.
- W2005261503 cites W1996180957 @default.
- W2005261503 cites W2001110380 @default.
- W2005261503 cites W2007770812 @default.
- W2005261503 cites W2007836961 @default.
- W2005261503 cites W2008280943 @default.
- W2005261503 cites W2010298858 @default.
- W2005261503 cites W2014578146 @default.
- W2005261503 cites W2015167201 @default.
- W2005261503 cites W2018365572 @default.
- W2005261503 cites W2018473508 @default.
- W2005261503 cites W2020490276 @default.
- W2005261503 cites W2028582699 @default.
- W2005261503 cites W2032028280 @default.
- W2005261503 cites W2034714392 @default.
- W2005261503 cites W2035567217 @default.
- W2005261503 cites W2037813923 @default.
- W2005261503 cites W2047281776 @default.
- W2005261503 cites W2048012249 @default.
- W2005261503 cites W2049521571 @default.
- W2005261503 cites W2054829079 @default.
- W2005261503 cites W2076050009 @default.
- W2005261503 cites W2080476827 @default.
- W2005261503 cites W2085188839 @default.
- W2005261503 cites W2086526888 @default.
- W2005261503 cites W2088935948 @default.
- W2005261503 cites W2092094013 @default.
- W2005261503 cites W2116275717 @default.
- W2005261503 cites W2117595378 @default.
- W2005261503 cites W2121897924 @default.
- W2005261503 cites W2123600404 @default.
- W2005261503 cites W2129695675 @default.
- W2005261503 cites W2146329250 @default.
- W2005261503 cites W2156179144 @default.
- W2005261503 cites W2161020639 @default.
- W2005261503 cites W2161193578 @default.
- W2005261503 cites W2170872843 @default.
- W2005261503 cites W2404197551 @default.
- W2005261503 cites W268515846 @default.
- W2005261503 cites W4237290129 @default.
- W2005261503 cites W4238204744 @default.
- W2005261503 doi "https://doi.org/10.1515/bc.2000.148" @default.
- W2005261503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11209755" @default.
- W2005261503 hasPublicationYear "2000" @default.
- W2005261503 type Work @default.
- W2005261503 sameAs 2005261503 @default.
- W2005261503 citedByCount "59" @default.
- W2005261503 countsByYear W20052615032012 @default.
- W2005261503 countsByYear W20052615032013 @default.
- W2005261503 countsByYear W20052615032014 @default.
- W2005261503 countsByYear W20052615032016 @default.
- W2005261503 countsByYear W20052615032017 @default.
- W2005261503 countsByYear W20052615032018 @default.
- W2005261503 countsByYear W20052615032019 @default.
- W2005261503 countsByYear W20052615032020 @default.
- W2005261503 countsByYear W20052615032021 @default.
- W2005261503 countsByYear W20052615032022 @default.
- W2005261503 countsByYear W20052615032023 @default.
- W2005261503 crossrefType "journal-article" @default.
- W2005261503 hasAuthorship W2005261503A5016898819 @default.
- W2005261503 hasAuthorship W2005261503A5036038504 @default.
- W2005261503 hasAuthorship W2005261503A5041040140 @default.
- W2005261503 hasAuthorship W2005261503A5051987821 @default.
- W2005261503 hasAuthorship W2005261503A5053305571 @default.
- W2005261503 hasAuthorship W2005261503A5061321693 @default.
- W2005261503 hasAuthorship W2005261503A5063495689 @default.
- W2005261503 hasAuthorship W2005261503A5065848878 @default.
- W2005261503 hasAuthorship W2005261503A5072138098 @default.
- W2005261503 hasConcept C153911025 @default.