Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005266181> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2005266181 endingPage "107" @default.
- W2005266181 startingPage "101" @default.
- W2005266181 abstract "We compared side effects with flecainide trough levels and ECG intervals among 43 patients who received flecainide for up to 34 months. Flecainide plasma levels were higher when associated with cardiovascular side effects (mean 1063 ng/ml; range 296 to 2050 ng/ml) than when no side effects occurred (mean 609 ng/ml; range 89 to 1508 ng/ml; P < 0.001). The PR interval (P < 0.001), QRS interval (P < 0.001), and the rate-corrected QT interval (P < 0.001) were greater at the time of cardiovascular side effects, but the rate-corrected JT interval was not. The therapeutic-toxic window for flecainide plasma level was 381 ng/ml (at least 50% probability of efficacy) to 710 ng/ml (<10% probability of cardiovascular side effects). The risk of cardiovascular side effects increases at higher plasma levels of flecainide and is associated with greater increases in the PR and QRS intervals from baseline than are routinely observed during flecainide dosing. Clinical Pharmacology and Therapeutics (1986) 40, 101–107; doi:10.1038/clpt.1986.145" @default.
- W2005266181 created "2016-06-24" @default.
- W2005266181 creator A5001851888 @default.
- W2005266181 creator A5002884005 @default.
- W2005266181 creator A5046285305 @default.
- W2005266181 creator A5052662934 @default.
- W2005266181 creator A5059145457 @default.
- W2005266181 creator A5073571977 @default.
- W2005266181 creator A5077207756 @default.
- W2005266181 creator A5079073098 @default.
- W2005266181 date "1986-07-01" @default.
- W2005266181 modified "2023-10-06" @default.
- W2005266181 title "Pharmacodynamics and side effects of flecainide acetate" @default.
- W2005266181 doi "https://doi.org/10.1038/clpt.1986.145" @default.
- W2005266181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3720173" @default.
- W2005266181 hasPublicationYear "1986" @default.
- W2005266181 type Work @default.
- W2005266181 sameAs 2005266181 @default.
- W2005266181 citedByCount "46" @default.
- W2005266181 countsByYear W20052661812012 @default.
- W2005266181 countsByYear W20052661812013 @default.
- W2005266181 countsByYear W20052661812014 @default.
- W2005266181 countsByYear W20052661812015 @default.
- W2005266181 countsByYear W20052661812016 @default.
- W2005266181 countsByYear W20052661812019 @default.
- W2005266181 countsByYear W20052661812020 @default.
- W2005266181 countsByYear W20052661812021 @default.
- W2005266181 countsByYear W20052661812022 @default.
- W2005266181 crossrefType "journal-article" @default.
- W2005266181 hasAuthorship W2005266181A5001851888 @default.
- W2005266181 hasAuthorship W2005266181A5002884005 @default.
- W2005266181 hasAuthorship W2005266181A5046285305 @default.
- W2005266181 hasAuthorship W2005266181A5052662934 @default.
- W2005266181 hasAuthorship W2005266181A5059145457 @default.
- W2005266181 hasAuthorship W2005266181A5073571977 @default.
- W2005266181 hasAuthorship W2005266181A5077207756 @default.
- W2005266181 hasAuthorship W2005266181A5079073098 @default.
- W2005266181 hasConcept C111113717 @default.
- W2005266181 hasConcept C111773187 @default.
- W2005266181 hasConcept C112705442 @default.
- W2005266181 hasConcept C118441451 @default.
- W2005266181 hasConcept C126322002 @default.
- W2005266181 hasConcept C164705383 @default.
- W2005266181 hasConcept C178697064 @default.
- W2005266181 hasConcept C199360897 @default.
- W2005266181 hasConcept C2777288759 @default.
- W2005266181 hasConcept C2777953023 @default.
- W2005266181 hasConcept C2779161974 @default.
- W2005266181 hasConcept C2779837460 @default.
- W2005266181 hasConcept C3020079912 @default.
- W2005266181 hasConcept C3454156 @default.
- W2005266181 hasConcept C41008148 @default.
- W2005266181 hasConcept C42219234 @default.
- W2005266181 hasConcept C71924100 @default.
- W2005266181 hasConcept C84393581 @default.
- W2005266181 hasConcept C98274493 @default.
- W2005266181 hasConceptScore W2005266181C111113717 @default.
- W2005266181 hasConceptScore W2005266181C111773187 @default.
- W2005266181 hasConceptScore W2005266181C112705442 @default.
- W2005266181 hasConceptScore W2005266181C118441451 @default.
- W2005266181 hasConceptScore W2005266181C126322002 @default.
- W2005266181 hasConceptScore W2005266181C164705383 @default.
- W2005266181 hasConceptScore W2005266181C178697064 @default.
- W2005266181 hasConceptScore W2005266181C199360897 @default.
- W2005266181 hasConceptScore W2005266181C2777288759 @default.
- W2005266181 hasConceptScore W2005266181C2777953023 @default.
- W2005266181 hasConceptScore W2005266181C2779161974 @default.
- W2005266181 hasConceptScore W2005266181C2779837460 @default.
- W2005266181 hasConceptScore W2005266181C3020079912 @default.
- W2005266181 hasConceptScore W2005266181C3454156 @default.
- W2005266181 hasConceptScore W2005266181C41008148 @default.
- W2005266181 hasConceptScore W2005266181C42219234 @default.
- W2005266181 hasConceptScore W2005266181C71924100 @default.
- W2005266181 hasConceptScore W2005266181C84393581 @default.
- W2005266181 hasConceptScore W2005266181C98274493 @default.
- W2005266181 hasIssue "1" @default.
- W2005266181 hasLocation W20052661811 @default.
- W2005266181 hasLocation W20052661812 @default.
- W2005266181 hasOpenAccess W2005266181 @default.
- W2005266181 hasPrimaryLocation W20052661811 @default.
- W2005266181 hasRelatedWork W1973023054 @default.
- W2005266181 hasRelatedWork W2016275322 @default.
- W2005266181 hasRelatedWork W2016665892 @default.
- W2005266181 hasRelatedWork W2041015223 @default.
- W2005266181 hasRelatedWork W2045578434 @default.
- W2005266181 hasRelatedWork W2046369244 @default.
- W2005266181 hasRelatedWork W2318894277 @default.
- W2005266181 hasRelatedWork W2412052983 @default.
- W2005266181 hasRelatedWork W2497548733 @default.
- W2005266181 hasRelatedWork W3021369409 @default.
- W2005266181 hasVolume "40" @default.
- W2005266181 isParatext "false" @default.
- W2005266181 isRetracted "false" @default.
- W2005266181 magId "2005266181" @default.
- W2005266181 workType "article" @default.