FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005280708> ?p ?o ?g. }

• W2005280708 endingPage "68" @default.
• W2005280708 startingPage "61" @default.
• W2005280708 abstract "Because the therapeutic use of the antitumor ether lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine (ET-18-OCH3) is restricted by its hemolytic activity we explored the use of lipid packing parameters to reduce this toxicity by creating structurally optimized ET-18-OCH3 liposomes. We postulated that combination of ET-18-OCH3, which is similar in structure to lysophosphatidylcholine, with lipid molecules of complementary molecular shape (opposite headgroup/chain volume) would likely yield a stable lamellar phase from which ET-18-OCH3 exchange to red blood cell membranes would be curtailed. To quantitate the degree of shape complementarity, we used a Langmuir trough and measured the mean molecular area per molecule (MMAM) for monolayers comprised of ET-18-OCH3, the host lipids, and binary mixtures of varying mole percentage ET-18-OCH3. The degree of complementarity was taken as the reduction in MMAM from the value expected based on simple additivity of the individual components. The greatest degree of shape complementarity was observed with cholesterol: the order of complementarity for the ET-18-OCH3-lipid mixtures examined was cholesterol>>DOPE>POPC≈DOPC. Phosphorus NMR and TLC analysis of aqueous suspensions of ET-18-OCH3 (40 mol%) with the host lipids revealed them to all be lamellar phase. For ET-18-OCH3 at 40 mol% in liposomes, the hemolytic activity followed the trend of the reduction in MMAM and was least for the ET-18-OCH3/cholesterol system (H50=661 μM ET-18-OCH3) followed by ET-18-OCH3/DOPE (H50=91 μM) and mixtures with POPC and DOPC which were comparable at H50=26 μM and 38 μM, respectively: the H50 concentration for free ET-18-OCH3 was 16 μM. This experimental strategy for designing optimized liposomes with a reduction in exchange, and hence toxicity, may be useful for other amphipathic/lipophilic drugs that are dimensionally compatible with lipid bilayers." @default.
• W2005280708 created "2016-06-24" @default.
• W2005280708 creator A5018977802 @default.
• W2005280708 creator A5024584577 @default.
• W2005280708 creator A5041316423 @default.
• W2005280708 creator A5044810050 @default.
• W2005280708 creator A5045851242 @default.
• W2005280708 creator A5046870824 @default.
• W2005280708 creator A5049874970 @default.
• W2005280708 creator A5086251221 @default.
• W2005280708 creator A5090747263 @default.
• W2005280708 date "1997-07-01" @default.
• W2005280708 modified "2023-09-30" @default.
• W2005280708 title "Combination of antitumor ether lipid with lipids of complementary molecular shape reduces its hemolytic activity" @default.
• W2005280708 cites W1964779269 @default.
• W2005280708 cites W1976467147 @default.
• W2005280708 cites W1985342306 @default.
• W2005280708 cites W1991044267 @default.
• W2005280708 cites W1995584045 @default.
• W2005280708 cites W2000966264 @default.
• W2005280708 cites W2004538436 @default.
• W2005280708 cites W2006912694 @default.
• W2005280708 cites W2018520958 @default.
• W2005280708 cites W2022601757 @default.
• W2005280708 cites W2035758027 @default.
• W2005280708 cites W2047225462 @default.
• W2005280708 cites W2049891698 @default.
• W2005280708 cites W2051105058 @default.
• W2005280708 cites W2078153934 @default.
• W2005280708 cites W2090410938 @default.
• W2005280708 cites W2104010651 @default.
• W2005280708 cites W2129309504 @default.
• W2005280708 cites W2149561805 @default.
• W2005280708 cites W2161959240 @default.
• W2005280708 cites W2333269083 @default.
• W2005280708 cites W329946383 @default.
• W2005280708 doi "https://doi.org/10.1016/s0005-2736(97)00043-6" @default.
• W2005280708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9247167" @default.
• W2005280708 hasPublicationYear "1997" @default.
• W2005280708 type Work @default.
• W2005280708 sameAs 2005280708 @default.
• W2005280708 citedByCount "40" @default.
• W2005280708 countsByYear W20052807082012 @default.
• W2005280708 countsByYear W20052807082013 @default.
• W2005280708 countsByYear W20052807082014 @default.
• W2005280708 countsByYear W20052807082015 @default.
• W2005280708 countsByYear W20052807082016 @default.
• W2005280708 countsByYear W20052807082018 @default.
• W2005280708 countsByYear W20052807082021 @default.
• W2005280708 countsByYear W20052807082022 @default.
• W2005280708 crossrefType "journal-article" @default.
• W2005280708 hasAuthorship W2005280708A5018977802 @default.
• W2005280708 hasAuthorship W2005280708A5024584577 @default.
• W2005280708 hasAuthorship W2005280708A5041316423 @default.
• W2005280708 hasAuthorship W2005280708A5044810050 @default.
• W2005280708 hasAuthorship W2005280708A5045851242 @default.
• W2005280708 hasAuthorship W2005280708A5046870824 @default.
• W2005280708 hasAuthorship W2005280708A5049874970 @default.
• W2005280708 hasAuthorship W2005280708A5086251221 @default.
• W2005280708 hasAuthorship W2005280708A5090747263 @default.
• W2005280708 hasBestOaLocation W20052807081 @default.
• W2005280708 hasConcept C178790620 @default.
• W2005280708 hasConcept C185154212 @default.
• W2005280708 hasConcept C185592680 @default.
• W2005280708 hasConcept C2779564620 @default.
• W2005280708 hasConcept C2780407432 @default.
• W2005280708 hasConcept C32909587 @default.
• W2005280708 hasConcept C43617362 @default.
• W2005280708 hasConcept C55493867 @default.
• W2005280708 hasConcept C71240020 @default.
• W2005280708 hasConcept C77851909 @default.
• W2005280708 hasConcept C8010536 @default.
• W2005280708 hasConceptScore W2005280708C178790620 @default.
• W2005280708 hasConceptScore W2005280708C185154212 @default.
• W2005280708 hasConceptScore W2005280708C185592680 @default.
• W2005280708 hasConceptScore W2005280708C2779564620 @default.
• W2005280708 hasConceptScore W2005280708C2780407432 @default.
• W2005280708 hasConceptScore W2005280708C32909587 @default.
• W2005280708 hasConceptScore W2005280708C43617362 @default.
• W2005280708 hasConceptScore W2005280708C55493867 @default.
• W2005280708 hasConceptScore W2005280708C71240020 @default.
• W2005280708 hasConceptScore W2005280708C77851909 @default.
• W2005280708 hasConceptScore W2005280708C8010536 @default.
• W2005280708 hasIssue "1" @default.
• W2005280708 hasLocation W20052807081 @default.
• W2005280708 hasLocation W20052807082 @default.
• W2005280708 hasOpenAccess W2005280708 @default.
• W2005280708 hasPrimaryLocation W20052807081 @default.
• W2005280708 hasRelatedWork W2043133834 @default.
• W2005280708 hasRelatedWork W2048121138 @default.
• W2005280708 hasRelatedWork W2054401684 @default.
• W2005280708 hasRelatedWork W2054879187 @default.
• W2005280708 hasRelatedWork W2125285463 @default.
• W2005280708 hasRelatedWork W2322557491 @default.
• W2005280708 hasRelatedWork W2382551095 @default.
• W2005280708 hasRelatedWork W2409566749 @default.
• W2005280708 hasRelatedWork W2412921235 @default.
• W2005280708 hasRelatedWork W2444223661 @default.

• next