FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005280807> ?p ?o ?g. }

• W2005280807 endingPage "510" @default.
• W2005280807 startingPage "499" @default.
• W2005280807 abstract "This study investigated the safety, pharmacokinetics, and pharmacodynamics of single oral doses of R1663, a factor Xa inhibitor, in healthy volunteers. It was a single-blind, randomized, crossover, placebo-controlled, dose escalation study in 33 healthy male volunteers aged 18 to 45 years. Each volunteer was dosed on 3 occasions with R1663 or placebo. Single oral doses of R1663 were safe and well tolerated. R1663 did not affect bleeding time. Pharmacodynamic effects (prothrombin time [PT], activated partial thromboplastin time [aPTT]), parameters of thrombogram, and anti-factor Xa activity) and plasma concentrations of R1663 were dose-dependent and showed low to moderate (<40%) intersubject and intrasubject variability. Maximum factor Xa inhibition was achieved 3 hours post dose (time to maximum concentration of R1663): clotting times were prolonged up to 2.5-fold, whereas endogenous thrombin potential (ETP) and peak height were decreased by 48% and 85% from their baseline values, respectively. Pharmacodynamic parameters were strongly correlated to R1663 plasma concentrations, with IC50 values of 182 and 2680 ng/mL for peak height and ETP, respectively. Oral doses of R1663 up to 480 mg were well tolerated, with predictable pharmacodynamics and pharmacokinetics. R1663 prolonged clotting times (PT, aPTT) and inhibited thrombin generation without increasing bleeding time." @default.
• W2005280807 created "2016-06-24" @default.
• W2005280807 creator A5020001100 @default.
• W2005280807 creator A5021345157 @default.
• W2005280807 creator A5043519794 @default.
• W2005280807 creator A5066034815 @default.
• W2005280807 creator A5073716781 @default.
• W2005280807 creator A5074818360 @default.
• W2005280807 creator A5079561949 @default.
• W2005280807 date "2012-04-01" @default.
• W2005280807 modified "2023-10-16" @default.
• W2005280807 title "Crossover Dose Escalation Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of R1663, an Oral Factor Xa Inhibitor, in Healthy Male Volunteers" @default.
• W2005280807 cites W1758514097 @default.
• W2005280807 cites W1973233314 @default.
• W2005280807 cites W1980669153 @default.
• W2005280807 cites W1982442692 @default.
• W2005280807 cites W1985842169 @default.
• W2005280807 cites W1996063108 @default.
• W2005280807 cites W2005066506 @default.
• W2005280807 cites W2007515753 @default.
• W2005280807 cites W2014491911 @default.
• W2005280807 cites W2022932023 @default.
• W2005280807 cites W2023320697 @default.
• W2005280807 cites W2027422208 @default.
• W2005280807 cites W2028092355 @default.
• W2005280807 cites W2028870588 @default.
• W2005280807 cites W2033190358 @default.
• W2005280807 cites W2041659695 @default.
• W2005280807 cites W2041726150 @default.
• W2005280807 cites W2045987573 @default.
• W2005280807 cites W2053780698 @default.
• W2005280807 cites W2063216514 @default.
• W2005280807 cites W2064826963 @default.
• W2005280807 cites W2066355180 @default.
• W2005280807 cites W2066676409 @default.
• W2005280807 cites W2077238944 @default.
• W2005280807 cites W2091101264 @default.
• W2005280807 cites W2091825028 @default.
• W2005280807 cites W2116489124 @default.
• W2005280807 cites W2122004095 @default.
• W2005280807 cites W2135486988 @default.
• W2005280807 cites W2150567120 @default.
• W2005280807 cites W2156320702 @default.
• W2005280807 cites W2768019923 @default.
• W2005280807 cites W4249394528 @default.
• W2005280807 cites W4296154158 @default.
• W2005280807 doi "https://doi.org/10.1177/0091270011401621" @default.
• W2005280807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21566199" @default.
• W2005280807 hasPublicationYear "2012" @default.
• W2005280807 type Work @default.
• W2005280807 sameAs 2005280807 @default.
• W2005280807 citedByCount "5" @default.
• W2005280807 countsByYear W20052808072012 @default.
• W2005280807 countsByYear W20052808072014 @default.
• W2005280807 countsByYear W20052808072020 @default.
• W2005280807 crossrefType "journal-article" @default.
• W2005280807 hasAuthorship W2005280807A5020001100 @default.
• W2005280807 hasAuthorship W2005280807A5021345157 @default.
• W2005280807 hasAuthorship W2005280807A5043519794 @default.
• W2005280807 hasAuthorship W2005280807A5066034815 @default.
• W2005280807 hasAuthorship W2005280807A5073716781 @default.
• W2005280807 hasAuthorship W2005280807A5074818360 @default.
• W2005280807 hasAuthorship W2005280807A5079561949 @default.
• W2005280807 hasConcept C111113717 @default.
• W2005280807 hasConcept C112705442 @default.
• W2005280807 hasConcept C126322002 @default.
• W2005280807 hasConcept C142724271 @default.
• W2005280807 hasConcept C186738567 @default.
• W2005280807 hasConcept C204787440 @default.
• W2005280807 hasConcept C27081682 @default.
• W2005280807 hasConcept C2776768635 @default.
• W2005280807 hasConcept C2777151630 @default.
• W2005280807 hasConcept C2777987278 @default.
• W2005280807 hasConcept C2778205648 @default.
• W2005280807 hasConcept C2778261982 @default.
• W2005280807 hasConcept C2778382381 @default.
• W2005280807 hasConcept C2780077467 @default.
• W2005280807 hasConcept C2780434524 @default.
• W2005280807 hasConcept C42219234 @default.
• W2005280807 hasConcept C6557445 @default.
• W2005280807 hasConcept C71924100 @default.
• W2005280807 hasConcept C86803240 @default.
• W2005280807 hasConcept C87813604 @default.
• W2005280807 hasConcept C98274493 @default.
• W2005280807 hasConceptScore W2005280807C111113717 @default.
• W2005280807 hasConceptScore W2005280807C112705442 @default.
• W2005280807 hasConceptScore W2005280807C126322002 @default.
• W2005280807 hasConceptScore W2005280807C142724271 @default.
• W2005280807 hasConceptScore W2005280807C186738567 @default.
• W2005280807 hasConceptScore W2005280807C204787440 @default.
• W2005280807 hasConceptScore W2005280807C27081682 @default.
• W2005280807 hasConceptScore W2005280807C2776768635 @default.
• W2005280807 hasConceptScore W2005280807C2777151630 @default.
• W2005280807 hasConceptScore W2005280807C2777987278 @default.
• W2005280807 hasConceptScore W2005280807C2778205648 @default.
• W2005280807 hasConceptScore W2005280807C2778261982 @default.
• W2005280807 hasConceptScore W2005280807C2778382381 @default.
• W2005280807 hasConceptScore W2005280807C2780077467 @default.

• next