Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005281359> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2005281359 endingPage "450" @default.
- W2005281359 startingPage "443" @default.
- W2005281359 abstract "Abstract The effects of ketonemia on brain carbohydrate metabolism of 20-day-old rats breathing air or 20% CO2 were studied. Intraperitoneal administration of sodium dl -β- hydroxybutyrate (8–10 mmol/kg) significantly reduced rates of glucose utilization by brains of both groups, as determined with [2-14C]glucose and [3H]deoxyglucose as tracers. The greater decrease found with [2-14C]glucose indicated that loss of a 14C-labeled intermediate from brain also occurred during ketonemia. Other investigators have observed release of lactate from brain into blood during ketonemia. It is likely that the loss of 14C was by this route. The decrease in rate of glucose utilization produced by ketonemia was additive with the decrease produced by hypercapnia. Changes in brain metabolite concentrations with ketonemia included increases in glucose, glucose 6-phosphate, pyruvate, citrate, α-ketoglutarate, malate, and glutamate. With the combination of ketonemia and hypercapnia there were further increases in brain glucose and glucose 6-phosphate concentrations, while the levels of the other metabolites fell to about the same or to a lesser extent as occurred with hypercapnia alone. These observations, coupled with those on rates of glucose utilization, support the following conclusions: (1) acute ketonemia diminished flux through the hexokinase, phosphofructokinase, and pyruvate dehydrogenase reactions, but total influx of substrates into the Krebs cycle temporarily exceeded CO2 evolution, leading to increased concentrations of cycle intermediates and glutamate; (2) hypercapnia superimposed on ketonemia had an additive inhibitory effect on phosphofructokinase activity; (3) during combined hypercapnia and ketonemia, there did not appear to be an adaptive increase in use of β-hydroxybutyrate by brain to compensate for the CO2-produced reduction in glucose use." @default.
- W2005281359 created "2016-06-24" @default.
- W2005281359 creator A5000014963 @default.
- W2005281359 creator A5016823238 @default.
- W2005281359 creator A5024882244 @default.
- W2005281359 creator A5049114475 @default.
- W2005281359 date "1982-08-01" @default.
- W2005281359 modified "2023-09-23" @default.
- W2005281359 title "Interactions between glucose and ketone body use by developing brain" @default.
- W2005281359 cites W105271699 @default.
- W2005281359 cites W1531062343 @default.
- W2005281359 cites W1827211888 @default.
- W2005281359 cites W1881476382 @default.
- W2005281359 cites W1938553409 @default.
- W2005281359 cites W1981607584 @default.
- W2005281359 cites W1984098580 @default.
- W2005281359 cites W1997050708 @default.
- W2005281359 cites W2002542943 @default.
- W2005281359 cites W2016761017 @default.
- W2005281359 cites W2036271397 @default.
- W2005281359 cites W2039924869 @default.
- W2005281359 cites W2047487540 @default.
- W2005281359 cites W2073524736 @default.
- W2005281359 cites W2080799845 @default.
- W2005281359 cites W2104938317 @default.
- W2005281359 cites W2135533559 @default.
- W2005281359 cites W2145615169 @default.
- W2005281359 cites W2146250938 @default.
- W2005281359 cites W2317009303 @default.
- W2005281359 cites W2338209918 @default.
- W2005281359 cites W2415262869 @default.
- W2005281359 cites W2473520419 @default.
- W2005281359 cites W998680019 @default.
- W2005281359 doi "https://doi.org/10.1016/0165-3806(82)90188-2" @default.
- W2005281359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6812860" @default.
- W2005281359 hasPublicationYear "1982" @default.
- W2005281359 type Work @default.
- W2005281359 sameAs 2005281359 @default.
- W2005281359 citedByCount "28" @default.
- W2005281359 countsByYear W20052813592014 @default.
- W2005281359 countsByYear W20052813592023 @default.
- W2005281359 crossrefType "journal-article" @default.
- W2005281359 hasAuthorship W2005281359A5000014963 @default.
- W2005281359 hasAuthorship W2005281359A5016823238 @default.
- W2005281359 hasAuthorship W2005281359A5024882244 @default.
- W2005281359 hasAuthorship W2005281359A5049114475 @default.
- W2005281359 hasConcept C134018914 @default.
- W2005281359 hasConcept C169760540 @default.
- W2005281359 hasConcept C31532488 @default.
- W2005281359 hasConcept C62231903 @default.
- W2005281359 hasConcept C86803240 @default.
- W2005281359 hasConceptScore W2005281359C134018914 @default.
- W2005281359 hasConceptScore W2005281359C169760540 @default.
- W2005281359 hasConceptScore W2005281359C31532488 @default.
- W2005281359 hasConceptScore W2005281359C62231903 @default.
- W2005281359 hasConceptScore W2005281359C86803240 @default.
- W2005281359 hasIssue "4" @default.
- W2005281359 hasLocation W20052813591 @default.
- W2005281359 hasLocation W20052813592 @default.
- W2005281359 hasOpenAccess W2005281359 @default.
- W2005281359 hasPrimaryLocation W20052813591 @default.
- W2005281359 hasRelatedWork W1641042124 @default.
- W2005281359 hasRelatedWork W1990804418 @default.
- W2005281359 hasRelatedWork W1993764875 @default.
- W2005281359 hasRelatedWork W2013243191 @default.
- W2005281359 hasRelatedWork W2020883942 @default.
- W2005281359 hasRelatedWork W2046158694 @default.
- W2005281359 hasRelatedWork W2082860237 @default.
- W2005281359 hasRelatedWork W2130076355 @default.
- W2005281359 hasRelatedWork W2151865869 @default.
- W2005281359 hasRelatedWork W4234157524 @default.
- W2005281359 hasVolume "4" @default.
- W2005281359 isParatext "false" @default.
- W2005281359 isRetracted "false" @default.
- W2005281359 magId "2005281359" @default.
- W2005281359 workType "article" @default.