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- W2005283166 abstract "The effects of hypoxia on the content of high-energy phosphates and on O2 consumption were studied in rat and guinea-pig heart. In the guinea-pig there were no changes in the biochemical indices studied after 6 hr hypoxia with 7.5% or 5% O2. In the rat at 7.5% O2 a progressive increase in the ATP content was noted between the 1st and 6th hr of the experiment. After 8 hr the increase in ATP was much less than after 6 hr but still above normal; after 12 hr the ATP value fell to below normal values. The trend of O2 consumption was roughly parallel with that of ATP. ADP and inorganic phosphate were also raised in hypoxic rat heart (assays done at 6 hr). The increase in the high-energy phosphates was scarcely affected by treatment with reserpine + propranolol and therefore was not mediated by the release of catecholamines. The increase was greatly reduced by pretreatment with lanatoside C. It is concluded that in hypoxia of the type induced in these experiments, there is, at least initially, an increase in the production of high-energy phosphates, parallel with the increase in cardiac output. This mechanism alone does not, however, fully account for the increase in ATP found, and probably hypoxia interferes in some way with the normal utilisation of energy by the myocardial cells." @default.
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- W2005283166 title "The effect of hypoxia on cardiac tissue (I) High energy phosphates content and oxygen uptake" @default.
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- W2005283166 doi "https://doi.org/10.1016/0014-2999(69)90124-1" @default.
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