FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005293013> ?p ?o ?g. }

• W2005293013 endingPage "e104804" @default.
• W2005293013 startingPage "e104804" @default.
• W2005293013 abstract "Dendritic cells (DCs) play a major role in the innate immune response since they recognize a broad repertoire of PAMPs mainly via Toll-like receptors (TLRs). During Helicobacter pylori (H. pylori) infection, TLRs have been shown to be important to control cytokine response particularly in murine DCs. In the present study we analyzed the effect of blocking TLRs on human DCs. Co-incubation of human DCs with H. pylori resulted in the release of the pro-inflammatory cytokines IL-12p70, IL-6 and IL-10. Release of IL-12p70 and IL-10 was predominantly influenced when TLR4 signaling was blocked by adding specific antibodies, suggesting a strong influence on subsequent T cell responses through TLR4 activation on DCs. Co-incubation of H. pylori-primed DC with allogeneic CD4+ T cells resulted in the production of IFN-γ and IL-17A as well as the expression of Foxp3, validating a mixed Th1/Th17 and Treg response in vitro. Neutralization of TLR4 during H. pylori infection resulted in significantly decreased amounts of IL-17A and IFN-γ and reduced levels of Foxp3-expressing and IL-10-secreting T cells. Our findings suggest that DC cytokine secretion induced upon TLR4-mediated recognition of H. pylori influences inflammatory and regulatory T cell responses, which might facilitate the chronic bacterial persistence." @default.
• W2005293013 created "2016-06-24" @default.
• W2005293013 creator A5027763220 @default.
• W2005293013 creator A5039775578 @default.
• W2005293013 creator A5039847078 @default.
• W2005293013 creator A5083657459 @default.
• W2005293013 date "2014-08-25" @default.
• W2005293013 modified "2023-09-29" @default.
• W2005293013 title "Involvement of Toll-Like Receptors on Helicobacter pylori-Induced Immunity" @default.
• W2005293013 cites W1561530553 @default.
• W2005293013 cites W1965263296 @default.
• W2005293013 cites W1969072247 @default.
• W2005293013 cites W1995744610 @default.
• W2005293013 cites W1996671942 @default.
• W2005293013 cites W2001142268 @default.
• W2005293013 cites W2004465286 @default.
• W2005293013 cites W2006366843 @default.
• W2005293013 cites W2006439698 @default.
• W2005293013 cites W2032148614 @default.
• W2005293013 cites W2039073863 @default.
• W2005293013 cites W2056654184 @default.
• W2005293013 cites W2069981713 @default.
• W2005293013 cites W2070429585 @default.
• W2005293013 cites W2077360946 @default.
• W2005293013 cites W2077486035 @default.
• W2005293013 cites W2092117527 @default.
• W2005293013 cites W2095495335 @default.
• W2005293013 cites W2100532498 @default.
• W2005293013 cites W2101367980 @default.
• W2005293013 cites W2103914727 @default.
• W2005293013 cites W2110768898 @default.
• W2005293013 cites W2127972686 @default.
• W2005293013 cites W2129085909 @default.
• W2005293013 cites W2131015336 @default.
• W2005293013 cites W2133449490 @default.
• W2005293013 cites W2141753982 @default.
• W2005293013 cites W2146737004 @default.
• W2005293013 cites W2149042360 @default.
• W2005293013 cites W2161503027 @default.
• W2005293013 cites W4322703275 @default.
• W2005293013 doi "https://doi.org/10.1371/journal.pone.0104804" @default.
• W2005293013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143222" @default.
• W2005293013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25153703" @default.
• W2005293013 hasPublicationYear "2014" @default.
• W2005293013 type Work @default.
• W2005293013 sameAs 2005293013 @default.
• W2005293013 citedByCount "17" @default.
• W2005293013 countsByYear W20052930132014 @default.
• W2005293013 countsByYear W20052930132015 @default.
• W2005293013 countsByYear W20052930132016 @default.
• W2005293013 countsByYear W20052930132017 @default.
• W2005293013 countsByYear W20052930132018 @default.
• W2005293013 countsByYear W20052930132020 @default.
• W2005293013 countsByYear W20052930132021 @default.
• W2005293013 countsByYear W20052930132023 @default.
• W2005293013 crossrefType "journal-article" @default.
• W2005293013 hasAuthorship W2005293013A5027763220 @default.
• W2005293013 hasAuthorship W2005293013A5039775578 @default.
• W2005293013 hasAuthorship W2005293013A5039847078 @default.
• W2005293013 hasAuthorship W2005293013A5083657459 @default.
• W2005293013 hasBestOaLocation W20052930131 @default.
• W2005293013 hasConcept C111289621 @default.
• W2005293013 hasConcept C136449434 @default.
• W2005293013 hasConcept C170493617 @default.
• W2005293013 hasConcept C187316574 @default.
• W2005293013 hasConcept C203014093 @default.
• W2005293013 hasConcept C2776070231 @default.
• W2005293013 hasConcept C2776409635 @default.
• W2005293013 hasConcept C2776709828 @default.
• W2005293013 hasConcept C2778690821 @default.
• W2005293013 hasConcept C2779727006 @default.
• W2005293013 hasConcept C54355233 @default.
• W2005293013 hasConcept C55493867 @default.
• W2005293013 hasConcept C86803240 @default.
• W2005293013 hasConcept C8891405 @default.
• W2005293013 hasConceptScore W2005293013C111289621 @default.
• W2005293013 hasConceptScore W2005293013C136449434 @default.
• W2005293013 hasConceptScore W2005293013C170493617 @default.
• W2005293013 hasConceptScore W2005293013C187316574 @default.
• W2005293013 hasConceptScore W2005293013C203014093 @default.
• W2005293013 hasConceptScore W2005293013C2776070231 @default.
• W2005293013 hasConceptScore W2005293013C2776409635 @default.
• W2005293013 hasConceptScore W2005293013C2776709828 @default.
• W2005293013 hasConceptScore W2005293013C2778690821 @default.
• W2005293013 hasConceptScore W2005293013C2779727006 @default.
• W2005293013 hasConceptScore W2005293013C54355233 @default.
• W2005293013 hasConceptScore W2005293013C55493867 @default.
• W2005293013 hasConceptScore W2005293013C86803240 @default.
• W2005293013 hasConceptScore W2005293013C8891405 @default.
• W2005293013 hasIssue "8" @default.
• W2005293013 hasLocation W20052930131 @default.
• W2005293013 hasLocation W20052930132 @default.
• W2005293013 hasLocation W20052930133 @default.
• W2005293013 hasLocation W20052930134 @default.
• W2005293013 hasOpenAccess W2005293013 @default.
• W2005293013 hasPrimaryLocation W20052930131 @default.
• W2005293013 hasRelatedWork W1974055405 @default.
• W2005293013 hasRelatedWork W1978048394 @default.

• next