FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005294016> ?p ?o ?g. }

• W2005294016 endingPage "2311" @default.
• W2005294016 startingPage "2306" @default.
• W2005294016 abstract "Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including chelocardin, anhydrotetracycline, 6-thiatetracycline, anhydrochlortetracycline, and 4-epi-anhydrochlortetracycline, failed to inhibit protein synthesis in vitro or were very poor inhibitors. Tetracyclines of the second class, however, rapidly inhibited the in vivo incorporation of precursors into DNA and RNA as well as protein. The class 2 compounds therefore have a mode of action that is entirely distinct from the class 1 compounds, such as tetracycline that are used clinically. Although tetracyclines of the second class entered the cytoplasm, the ability of these analogs to inhibit macromolecular synthesis suggests that the cytoplasmic membrane is their primary site of action. The interaction of class 1 and class 2 tetracyclines with ribosomes was studied by examining their effects on the chemical reactivity of bases in 16S rRNA to dimethyl sulfate. Class 1 analogs affected the reactivity of bases to dimethyl sulfate. The response with class 2 tetracyclines varied, with some analogs affecting reactivity and others (chelocardin and 4-epi-anhydrotetracycline) not." @default.
• W2005294016 created "2016-06-24" @default.
• W2005294016 creator A5006683119 @default.
• W2005294016 creator A5018710235 @default.
• W2005294016 creator A5020997526 @default.
• W2005294016 creator A5025925692 @default.
• W2005294016 creator A5031579787 @default.
• W2005294016 creator A5035635875 @default.
• W2005294016 creator A5044018267 @default.
• W2005294016 creator A5062234987 @default.
• W2005294016 creator A5068983783 @default.
• W2005294016 creator A5080921801 @default.
• W2005294016 date "1991-11-01" @default.
• W2005294016 modified "2023-10-14" @default.
• W2005294016 title "Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome" @default.
• W2005294016 cites W1486369891 @default.
• W2005294016 cites W1546783991 @default.
• W2005294016 cites W1745892296 @default.
• W2005294016 cites W1818316430 @default.
• W2005294016 cites W1838789895 @default.
• W2005294016 cites W2018429609 @default.
• W2005294016 cites W2026358434 @default.
• W2005294016 cites W2042814467 @default.
• W2005294016 cites W2053328600 @default.
• W2005294016 cites W2056495121 @default.
• W2005294016 cites W2060657665 @default.
• W2005294016 cites W2092541352 @default.
• W2005294016 cites W2100329115 @default.
• W2005294016 cites W2174331966 @default.
• W2005294016 cites W2230785030 @default.
• W2005294016 cites W2413245171 @default.
• W2005294016 doi "https://doi.org/10.1128/aac.35.11.2306" @default.
• W2005294016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245376" @default.
• W2005294016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1725100" @default.
• W2005294016 hasPublicationYear "1991" @default.
• W2005294016 type Work @default.
• W2005294016 sameAs 2005294016 @default.
• W2005294016 citedByCount "87" @default.
• W2005294016 countsByYear W20052940162012 @default.
• W2005294016 countsByYear W20052940162013 @default.
• W2005294016 countsByYear W20052940162014 @default.
• W2005294016 countsByYear W20052940162015 @default.
• W2005294016 countsByYear W20052940162016 @default.
• W2005294016 countsByYear W20052940162017 @default.
• W2005294016 countsByYear W20052940162018 @default.
• W2005294016 countsByYear W20052940162019 @default.
• W2005294016 countsByYear W20052940162020 @default.
• W2005294016 countsByYear W20052940162021 @default.
• W2005294016 countsByYear W20052940162022 @default.
• W2005294016 countsByYear W20052940162023 @default.
• W2005294016 crossrefType "journal-article" @default.
• W2005294016 hasAuthorship W2005294016A5006683119 @default.
• W2005294016 hasAuthorship W2005294016A5018710235 @default.
• W2005294016 hasAuthorship W2005294016A5020997526 @default.
• W2005294016 hasAuthorship W2005294016A5025925692 @default.
• W2005294016 hasAuthorship W2005294016A5031579787 @default.
• W2005294016 hasAuthorship W2005294016A5035635875 @default.
• W2005294016 hasAuthorship W2005294016A5044018267 @default.
• W2005294016 hasAuthorship W2005294016A5062234987 @default.
• W2005294016 hasAuthorship W2005294016A5068983783 @default.
• W2005294016 hasAuthorship W2005294016A5080921801 @default.
• W2005294016 hasBestOaLocation W20052940161 @default.
• W2005294016 hasConcept C104317684 @default.
• W2005294016 hasConcept C10879258 @default.
• W2005294016 hasConcept C185592680 @default.
• W2005294016 hasConcept C2777179404 @default.
• W2005294016 hasConcept C2777272437 @default.
• W2005294016 hasConcept C2780923616 @default.
• W2005294016 hasConcept C3675279 @default.
• W2005294016 hasConcept C501593827 @default.
• W2005294016 hasConcept C523546767 @default.
• W2005294016 hasConcept C54355233 @default.
• W2005294016 hasConcept C547475151 @default.
• W2005294016 hasConcept C55493867 @default.
• W2005294016 hasConcept C67705224 @default.
• W2005294016 hasConcept C86803240 @default.
• W2005294016 hasConcept C88478588 @default.
• W2005294016 hasConceptScore W2005294016C104317684 @default.
• W2005294016 hasConceptScore W2005294016C10879258 @default.
• W2005294016 hasConceptScore W2005294016C185592680 @default.
• W2005294016 hasConceptScore W2005294016C2777179404 @default.
• W2005294016 hasConceptScore W2005294016C2777272437 @default.
• W2005294016 hasConceptScore W2005294016C2780923616 @default.
• W2005294016 hasConceptScore W2005294016C3675279 @default.
• W2005294016 hasConceptScore W2005294016C501593827 @default.
• W2005294016 hasConceptScore W2005294016C523546767 @default.
• W2005294016 hasConceptScore W2005294016C54355233 @default.
• W2005294016 hasConceptScore W2005294016C547475151 @default.
• W2005294016 hasConceptScore W2005294016C55493867 @default.
• W2005294016 hasConceptScore W2005294016C67705224 @default.
• W2005294016 hasConceptScore W2005294016C86803240 @default.
• W2005294016 hasConceptScore W2005294016C88478588 @default.
• W2005294016 hasIssue "11" @default.
• W2005294016 hasLocation W20052940161 @default.
• W2005294016 hasLocation W20052940162 @default.
• W2005294016 hasLocation W20052940163 @default.
• W2005294016 hasOpenAccess W2005294016 @default.
• W2005294016 hasPrimaryLocation W20052940161 @default.

• next