Matches in SemOpenAlex for { <https://semopenalex.org/work/W2005295945> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2005295945 endingPage "301" @default.
- W2005295945 startingPage "299" @default.
- W2005295945 abstract "Azathioprine is an immunosuppressor drug widely used in the treatment of autoimmune diseases. Adverse effects during treatment are related to the activity of thiopurine methyltransferase (TPMT), an enzyme which plays a role in azathioprine metabolism. The presence of the allelic variants of the TPMT gene allows us to classify patients into three different groups: high, moderate and low risk of myelosuppression after receiving standard doses of azathioprine.Study of the allelic variants of the TPMT gene in the positions 460 and 719 with PCR methods in a patient with Crohn's disease, who developed aplasia after receiving azathioprine. The study was extended to his relatives.The patient under study carried the most frequent variant allele of the TPMT gene associated with low enzymatic activity. The mother and one sister of the patient were also carriers of this allelic variant.Genotyping the allelic variants of the TPMT gene is a useful method to identify patients at moderate or high risk of myelosuppression after administration of azathioprine." @default.
- W2005295945 created "2016-06-24" @default.
- W2005295945 creator A5024293034 @default.
- W2005295945 creator A5025787885 @default.
- W2005295945 creator A5028508664 @default.
- W2005295945 creator A5069537219 @default.
- W2005295945 creator A5079951138 @default.
- W2005295945 creator A5080734034 @default.
- W2005295945 creator A5081728369 @default.
- W2005295945 creator A5086726315 @default.
- W2005295945 date "2000-01-01" @default.
- W2005295945 modified "2023-10-18" @default.
- W2005295945 title "Aplasia medular tras administración de azatioprina: papel del polimorfismo genético de la tiopurina metiltransferasa" @default.
- W2005295945 cites W1491566276 @default.
- W2005295945 cites W1968809716 @default.
- W2005295945 cites W1990743262 @default.
- W2005295945 cites W1996409190 @default.
- W2005295945 cites W2011713807 @default.
- W2005295945 cites W2029841402 @default.
- W2005295945 cites W2034709553 @default.
- W2005295945 cites W2085038188 @default.
- W2005295945 cites W2090549398 @default.
- W2005295945 cites W2118094114 @default.
- W2005295945 cites W2156950528 @default.
- W2005295945 cites W2402574446 @default.
- W2005295945 doi "https://doi.org/10.1016/s0025-7753(00)71540-5" @default.
- W2005295945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11093885" @default.
- W2005295945 hasPublicationYear "2000" @default.
- W2005295945 type Work @default.
- W2005295945 sameAs 2005295945 @default.
- W2005295945 citedByCount "13" @default.
- W2005295945 countsByYear W20052959452016 @default.
- W2005295945 countsByYear W20052959452019 @default.
- W2005295945 crossrefType "journal-article" @default.
- W2005295945 hasAuthorship W2005295945A5024293034 @default.
- W2005295945 hasAuthorship W2005295945A5025787885 @default.
- W2005295945 hasAuthorship W2005295945A5028508664 @default.
- W2005295945 hasAuthorship W2005295945A5069537219 @default.
- W2005295945 hasAuthorship W2005295945A5079951138 @default.
- W2005295945 hasAuthorship W2005295945A5080734034 @default.
- W2005295945 hasAuthorship W2005295945A5081728369 @default.
- W2005295945 hasAuthorship W2005295945A5086726315 @default.
- W2005295945 hasConcept C138885662 @default.
- W2005295945 hasConcept C153911025 @default.
- W2005295945 hasConcept C15708023 @default.
- W2005295945 hasConcept C71924100 @default.
- W2005295945 hasConcept C86803240 @default.
- W2005295945 hasConceptScore W2005295945C138885662 @default.
- W2005295945 hasConceptScore W2005295945C153911025 @default.
- W2005295945 hasConceptScore W2005295945C15708023 @default.
- W2005295945 hasConceptScore W2005295945C71924100 @default.
- W2005295945 hasConceptScore W2005295945C86803240 @default.
- W2005295945 hasIssue "8" @default.
- W2005295945 hasLocation W20052959451 @default.
- W2005295945 hasLocation W20052959452 @default.
- W2005295945 hasOpenAccess W2005295945 @default.
- W2005295945 hasPrimaryLocation W20052959451 @default.
- W2005295945 hasRelatedWork W1964436858 @default.
- W2005295945 hasRelatedWork W2072914913 @default.
- W2005295945 hasRelatedWork W2108849469 @default.
- W2005295945 hasRelatedWork W2114405315 @default.
- W2005295945 hasRelatedWork W2123818508 @default.
- W2005295945 hasRelatedWork W2132433180 @default.
- W2005295945 hasRelatedWork W2148071778 @default.
- W2005295945 hasRelatedWork W2153381054 @default.
- W2005295945 hasRelatedWork W2897419016 @default.
- W2005295945 hasRelatedWork W3024013959 @default.
- W2005295945 hasVolume "115" @default.
- W2005295945 isParatext "false" @default.
- W2005295945 isRetracted "false" @default.
- W2005295945 magId "2005295945" @default.
- W2005295945 workType "article" @default.