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• W2005296308 abstract "Nodal status is an important prognostic factor and a major determinant for the staging and clinical management of NSCLC. The vascular endothelial growth factors (VEGFs) and the vascular endothelial growth factor receptors (VEGFRs) are important molecular markers in angiogenesis and lymphangiogenesis. In this study, we aimed to extensively investigate the correlations between lymph node metastasis and the VEGFs and VEGFRs in tumor cells as well as in the tumor stroma. Tumor tissue samples from 335 resected patients with stage I to IIIA were obtained and tissue microarrays were constructed from duplicate cores of tumor cells and surrounding stromal tissue from each resected specimen. Immunohistochemistry was used to evaluate the expression of VEGF-A, VEGF-C, VEGF-D, VEGFR-1, VEGFR-2 and VEGFR-3. There were 232 lymph node metastasis negative- and 103 lymph node metastasis positive patients (76 N1, 27 N2). In univariate analyses (Chi-square test), high tumor cell expression of VEGF-A (P = .011) and VEGFR-3 (P < .001) correlated with lymph node metastasis. In tumor stroma, however, low expression of VEGF-A (P = .037) and VEGFR-3 (P = .033), correlated with lymph node metastasis. There were no significant correlations between tumor cell or stromal expression of VEGF-C, VEGF-D, VEGFR-1 or VEGFR-2 and lymph node metastasis. Though, high tumor cell expression of VEGFR-1 (P = .065) and low stromal expression of VEGFR-1 (P = .075) tended towards correlation with lymph node metastasis. In multivariate analyses (Binary logistic regression), including clinicopathogical variables and angiogenic markers, high tumor cell expression of VEGF-A (P = .032, HR 1.8, 95% CI 1.1-3.1), low stromal expression of VEGF-A (P = .025, HR 3.1, 95% CI 1.2 - 8.3) and poor differentiation (P < .001, HR 3.4, 95% CI 2.0-5.9) correlated with lymph node positive patients. High tumor cell expression of VEGFR-3 (P < .001, HR 6.1, 95% CI 2.1-17.6) and vascular infiltration (P = .011, HR 3.9, 95% CI 1.4-11.2) correlated with N2 positivity. In tumor cells, there are strong correlations between high VEGFR-3 expression and N2-status and high VEGF-A expression and lymph node metastasis. While in stroma, low VEGF-A expression is associated with lymph node metastasis." @default.
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• W2005296308 date "2007-08-01" @default.
• W2005296308 modified "2023-09-30" @default.
• W2005296308 title "A6-04: Expression of vascular endothelial growth factors (VEGFs) A, C, D and receptors (VEGFRs) 1, 2 and 3, in both tumor cells and tumor stroma of non-small cell lung cancer (NSCLC): correlation with lymph node metastasis" @default.
• W2005296308 doi "https://doi.org/10.1097/01.jto.0000283128.98024.a5" @default.
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